ArticleThe Journal of pediatrics2014
Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments.
Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 161 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Supporting and Enhancing NICU Sensory Experiences to Optimize Developmental Outcomes in Preterm Infants
Neurodevelopmental Outcomes at Three Years of Age in Very Preterm Infants (< 31 Weeks Gestational Age) or Very Low Birth Weight (< 1500 Grams) Randomized to Single Patient Rooms Compared to Open Bay Neonatal Intensive Care Unit
Serial Neuroimaging of Brain Injury and Brain Growth in the NICU in the Very Preterm Infant
Who cites it
161 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The effects of the introduction of the single-family room in neonatal and paediatric intensive care on the outcomes of paediatric patients, families, staff, and organizations: a mixed method systematic review.BMC health services research · 2025Pooled it
- Noise or sound management in the neonatal intensive care unit for preterm or very low birth weight infants.The Cochrane database of systematic reviews · 2024Pooled it
- Musical and vocal interventions to improve neurodevelopmental outcomes for preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- The prevalence and profile of autism in individuals born preterm: a systematic review and meta-analysis.Journal of neurodevelopmental disorders · 2021Pooled it
- Do NICU developmental care improve cognitive and motor outcomes for preterm infants? A systematic review and meta-analysis.BMC pediatrics · 2020Pooled it
- Sound reduction management in the neonatal intensive care unit for preterm or very low birth weight infants.The Cochrane database of systematic reviews · 2020Pooled it
- Randomized trial evaluating sensorimotor stimulation and functional feeding in high-risk newborns: study protocol.Pediatric research · 2026Trial
- Breastmilk as a Multisensory Intervention for Relieving Pain during Newborn Screening Procedures: A Randomized Control Trial.International journal of environmental research and public health · 2021Trial
- Randomized clinical trial investigating the effect of consistent, developmentally-appropriate, and evidence-based multisensory exposures in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- A pilot study to assess the safety, efficacy and ease of use of a novel hearing protection device for hospitalized neonates.Early human development · 2021Trial
- Effect of Fortification of Breast Milk in Conjugation with Protein Supplement on Neurodevelopment of Preterm Low Birth Weight Infants at 3 Years.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2019Trial
- Trial
- Effects of standardized acoustic stimulation in premature infants: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2016Trial
- A pacifier-activated music player with mother's voice improves oral feeding in preterm infants.Pediatrics · 2014Trial
- Effectiveness of physiological flexion swaddling and oromotor interventions in improving preterm infants' oral feeding ability in the NICU: a randomized controlled trial.Jornal de pediatriaTrial
- Effects of hydrotherapy and tactile-kinesthetic stimulation on weight gain of preterm infants admitted in the Neonatal Intensive Care Unit.Jornal de pediatriaTrial
- Long-term outcomes of preterm infants admitted to single-family rooms versus an open-bay neonatal intensive care unit: A randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Translational Initiative to Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury.Bioengineering (Basel, Switzerland) · 2026Article
- Language and sound exposure across neonatal intensive care hospitalization and relationships with early outcome.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Review
101 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
objectiveTo evaluate associations between neonatal intensive care unit (NICU) room type (open ward and private room) and medical outcomes; neurobehavior, electrophysiology, and brain structure at hospital discharge; and developmental outcomes at 2 years of age. STUDY
designIn this prospective longitudinal cohort study, we enrolled 136 preterm infants born <30 weeks gestation from an urban, 75-bed level III NICU from 2007-2010. Upon admission, each participant was assigned to a bedspace in an open ward or private room within the same hospital, based on space and staffing availability, where they remained for the duration of hospitalization. The primary outcome was developmental performance at 2 years of age (n = 86 infants returned for testing, which was 83% of survivors) measured using the Bayley Scales of Infant and Toddler Development, 3rd Edition. Secondary outcomes were: (1) medical factors throughout the hospitalization; (2) neurobehavior; and (3) cerebral injury and maturation (determined by magnetic resonance imaging and electroencephalography).
resultsAt term equivalent age, infants in private rooms were characterized by a diminution of normal hemispheric asymmetry and a trend toward having lower amplitude integrated electroencephalography cerebral maturation scores (P = .02; β = -0.52 [CI -0.95, -0.10]). At age 2 years, infants from private rooms had lower language scores (P = .006; β = -8.3 [CI -14.2, -2.4]) and a trend toward lower motor scores (P = .02; β = -6.3 [CI -11.7, -0.99]), which persisted after adjustment for potential confounders.
conclusionThese findings raise concerns that highlight the need for further research into the potential adverse effects of different amounts of sensory exposure in the NICU environment.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.