Trial reportThe Journal of allergy and clinical immunology2014
Childhood asthma clusters and response to therapy in clinical trials.
Trial report in The Journal of allergy and clinical immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma.The journal of allergy and clinical immunology. In practiceTrial
- Early-Life Wheezing and Atopic Burden Are Associated with Treatment-Defined Asthma Severity and Control in School-Age Children: A Two-Center Cross-Sectional Study.Journal of clinical medicine · 2026Article
- MicroRNA clustering in pediatric asthma reveals differential corticosteroid responsiveness.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Asthma Phenotypes and Biomarkers.Respiratory care · 2025Review
- A clinician's guide to effects of obesity on childhood asthma and into adulthood.Expert review of respiratory medicine · 2024Review
- Childhood asthma phenotypes and endotypes: a glance into the mosaic.Molecular and cellular pediatrics · 2023Review
- Phenotypes and Endotypes in Asthma.Advances in experimental medicine and biology · 2023Article
- Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts.American journal of respiratory and critical care medicine · 2022Article
- Risk, Mechanisms and Implications of Asthma-Associated Infectious and Inflammatory Multimorbidities (AIMs) among Individuals With Asthma: a Systematic Review and a Case Study.Allergy, asthma & immunology research · 2021Review
- Treatment outcome clustering patterns correspond to discrete asthma phenotypes in children.Asthma research and practice · 2021Article
- Treating severe asthma: Targeting the IL-5 pathway.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Review
- Defining pediatric asthma: phenotypes to endotypes and beyond.Pediatric research · 2021Review
- Identification of Specific IgE Antibodies and Asthma Control Interaction and Association Using Cluster Analysis in a Bulgarian Asthmatic Children Cohort.Antibodies (Basel, Switzerland) · 2020Article
- Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?Physiological reviews · 2020Review
- Expression of corticosteroid-regulated genes by PBMCs in children with asthma.The Journal of allergy and clinical immunology · 2019Article
- Blood Biomarkers of Sensitization and Asthma.Frontiers in pediatrics · 2019Review
- A simple prediction tool for inhaled corticosteroid response in asthmatic children.BMC pulmonary medicine · 2017Article
- Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients.The Journal of allergy and clinical immunology · 2017Review
- Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma.Tuberculosis and respiratory diseases · 2017Review
- Asthma phenotypes in inner-city children.The Journal of allergy and clinical immunology · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundChildhood asthma clusters, or subclasses, have been developed by computational methods without evaluation of clinical utility.
objectiveTo replicate and determine whether childhood asthma clusters previously identified computationally in the Severe Asthma Research Program (SARP) are associated with treatment responses in Childhood Asthma Research and Education (CARE) Network clinical trials.
methodsA cluster assignment model was determined by using SARP participant data. A total of 611 participants 6 to 18 years old from 3 CARE trials were assigned to SARP pediatric clusters. Primary and secondary outcomes were analyzed by cluster in each trial.
resultsCARE participants were assigned to SARP clusters with high accuracy. Baseline characteristics were similar between SARP and CARE children of the same cluster. Treatment response in CARE trials was generally similar across clusters. However, with the caveat of a smaller sample size, children in the early-onset/severe-lung function cluster had best response with fluticasone/salmeterol (64% vs 23% 2.5× fluticasone and 13% fluticasone/montelukast in the Best ADd-on Therapy Giving Effective Responses trial; P = .011) and children in the early-onset/comorbidity cluster had the least clinical efficacy to treatments (eg, -0.076% change in FEV1 in the Characterizing Response to Leukotriene Receptor Antagonist and Inhaled Corticosteroid trial).
conclusionsIn this study, we replicated SARP pediatric asthma clusters by using a separate, large clinical trials network. Early-onset/severe-lung function and early-onset/comorbidity clusters were associated with differential and limited response to therapy, respectively. Further prospective study of therapeutic response by cluster could provide new insights into childhood asthma treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.