Evidence map›Paper›PMID 24139138›Full record

Observational studyJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2014

Apolipoprotein E-ε4 polymorphism and cognitive dysfunction after carotid endarterectomy.

Eric J Heyer, Joanna L Mergeche, Yaakov Stern, Hani R Malone, Samuel S Bruce, Justin T Ward, E Sander Connolly

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Genetic Polymorphisms Influence Cognition in Patients Undergoing Carotid Interventions.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric J HeyerDepartment of Anesthesiology, Columbia University, 630 West 168th Street, P&S Box 46, New York, NY 10032, USA; Department of Neurology, Columbia University, New York, NY, USA. Electronic address: ejh3@columbia.edu.
Joanna L MergecheDepartment of Anesthesiology, Columbia University, 630 West 168th Street, P&S Box 46, New York, NY 10032, USA.
Yaakov SternDepartment of Neurology, Columbia University, New York, NY, USA.
Hani R MaloneDepartment of Neurological Surgery, Columbia University, New York, NY, USA.
Samuel S BruceDepartment of Neurological Surgery, Columbia University, New York, NY, USA.
Justin T WardDepartment of Anesthesiology, Columbia University, 630 West 168th Street, P&S Box 46, New York, NY 10032, USA.
E Sander ConnollyDepartment of Neurology, Columbia University, New York, NY, USA; Department of Neurological Surgery, Columbia University, New York, NY, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Neuropsychological Outcome of Carotid EndarterectomyR01AG017604 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HEYER, ERIC JOHN · 2001 to 2012
$3.2M
NCATS NIH HHS UL1 TR000040NCRR NIH HHS UL1 RR024156NIA NIH HHS R01 AG017604NIA NIH HHS R01 AG17604
6 · The paper itself

Abstract

Approximately 25% of patients undergoing carotid endarterectomy (CEA) exhibit cognitive dysfunction (CD) 1 day and 1 month after CEA. The apolipoprotein E (apoE)-ε4 polymorphism has been previously identified as a robust independent risk factor for CD 1 month after CEA. We aimed to determine whether the apoE-ε4 polymorphism is also an independent risk factor for CD as early as 1 day after CEA and to confirm the previous findings at 1 month. Patients undergoing elective CEA (n=411) were enrolled with written informed consent in this follow-up observational study. CD was evaluated via an extensive neuropsychometric battery. apoE-ε4 carriers exhibited significantly more CD 1 day (30.1% versus 17.9%, p=0.01) and 1 month (25.7% versus 9.8%, p=0.001) after CEA compared to non-carriers. Multivariate regression models were generated to determine independent predictors of CD. At 1 day, apoE-ε4 was significantly associated with higher risk of CD (odds ratio [OR]: 2.24 [95% confidence interval 1.29-3.84], p=0.004), while statin use was significantly associated with lower risk (OR: 0.40 [0.24-0.67], p<0.001). At 1 month, apoE-ε4 was significantly associated with higher risk of CD (OR: 3.14 [1.53-6.38], p=0.002), while symptomatic status was significantly associated with lower risk (OR: 0.45 [0.20-0.94], p=0.03). The apoE-ε4 polymorphism is an independent risk factor for CD as early as 1 day after CEA and is confirmed to be an independent risk factor for CD at 1 month as well.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticAgedApolipoprotein E4Carotid StenosisCognition DisordersEndarterectomy, CarotidFemaleFollow-Up StudiesHeterozygoteHumansLogistic ModelsMaleMultivariate AnalysisNeuropsychological TestsRisk FactorsApolipoprotein E4Apolipoprotein ECarotid endarterectomyCognitionCognitive dysfunction

Identifiers

PMID24139138
PMCPMC3947092

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.