ArticleEnvironmental research2013
An exploratory study of ambient air toxics exposure in pregnancy and the risk of neuroblastoma in offspring.
Article in Environmental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02786420 (Imaging Innovations for Placental Assessment in Response to Environmental Pollution), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Innovations for Placental Assessment in Response to Environmental Pollution
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Childhood cancer and residential proximity to petrol stations: a nationwide registry-based case-control study in Switzerland and an updated meta-analysis.International archives of occupational and environmental health · 2022Pooled it
- Spatial analysis of residential location at birth, PFAS in public water, and childhood cancers in Southern California (2000-2019).Journal of exposure science & environmental epidemiology · 2026Article
- Establishing environmental causes of childhood cancer: a view from the IARC Monographs.UCL open. Environment · 2026Article
- The relative contributions of genetic and non-genetic factors to the risk of neuroblastoma.Pediatric investigation · 2025Review
- Cytotoxicity Modulated by Cyanotoxins in Neuroblastoma SH-SY5Y Cells.Journal of Experimental Pathology · 2025Article
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Environmental, social and behavioral risk factors in association with spatial clustering of childhood cancer incidence.Spatial and spatio-temporal epidemiology · 2023Article
- Inhibitory Effects of 3-Methylcholanthrene Exposure on Porcine Oocyte Maturation.International journal of molecular sciences · 2023Article
- Nutraceutical Preventative and Therapeutic Potential in Neuroblastoma: From Pregnancy to Early Childhood.Life (Basel, Switzerland) · 2022Review
- A brief review of the current knowledge on environmental toxicants and risk of pediatric cancers.Pediatric hematology and oncology · 2022Review
- Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring.International journal of environmental research and public health · 2018Article
- Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage.Cancer management and research · 2018Article
- Childhood cancer in small geographical areas and proximity to air-polluting industries.Environmental research · 2017Article
- Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics.Cancer epidemiology · 2017Article
- Differences in environmental exposure assignment due to residential mobility among children with a central nervous system tumor: Texas, 1995-2009.Journal of exposure science & environmental epidemiology · 2017Article
- Opportunities During Early Life for Cancer Prevention: Highlights From a Series of Virtual Meetings With Experts.Pediatrics · 2016Article
- In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case-Control Study in California, USA.Environmental health perspectives · 2016Article
- Article
- Temporal clustering of neuroblastic tumours in children and young adults from Northern England.Environmental health : a global access science source · 2015Article
- Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the etiology of neuroblastoma, the most common cancer in infancy. In this study, we examined maternal exposure to ambient air toxics in pregnancy in relation to neuroblastoma in the child. We ascertained all cases of neuroblastoma listed in the California Cancer Registry 1990-2007 that could be linked to a California birth certificate, and controls were selected at random from California birth records. Average air toxics exposures during pregnancy were determined based upon measures from community-based air pollution monitors. The study included 75 cases and 14,602 controls who lived with 5 km of an air pollution monitor, and we additionally examined results for those living within a smaller radius around the monitor (2.5 km). Logistic regression was used to determine the risk of neuroblastoma with one interquartile range increase in air toxic exposure. Neuroblastoma risk was increased with higher maternal exposure to carbon tetrachloride (OR=2.65, 95%CI 1.07, 6.53) and polycyclic aromatic hydrocarbons (OR=1.39, 95%CI 1.05, 1.84), particularly indeno(1,2,3-cd)pyrene and dibenz(a,h)anthracene. Hexavalent chromium was associated with neuroblastoma at the 5 km distance (OR=1.32, 95%CI 1.00, 1.74) but not at the 2.5 km distance. This is one of the first studies to report associations between neuroblastoma and these air toxics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.