ArticleNeuron2013
Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
- Modeling impaired insight after drug use in rodents.Behavioral neuroscience · 2024Review
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
- OFC neurons do not represent the negative value of a conditioned inhibitor.Neurobiology of learning and memory · 2024Article
- Lateral orbitofrontal cortex integrates predictive information across multiple cues to guide behavior.Current biology : CB · 2023Article
- How Instructions, Learning, and Expectations Shape Pain and Neurobiological Responses.Annual review of neuroscience · 2023Review
- Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters.Psychopharmacology · 2023Article
- A neural signature of the vividness of prospective thought is modulated by temporal proximity during intertemporal decision making.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hippocampal signals modify orbitofrontal representations to learn new paths.Current biology : CB · 2022Article
- Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Subpopulations of neurons in lOFC encode previous and current rewards at time of choice.eLife · 2021Article
- Is the core function of orbitofrontal cortex to signal values or make predictions?Current opinion in behavioral sciences · 2021Article
- Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making.Behavioural brain research · 2021Review
- A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories.eLife · 2021Article
- Cross-species studies on orbitofrontal control of inference-based behavior.Behavioral neuroscience · 2021Article
- Article
- The Role of the Rodent Lateral Orbitofrontal Cortex in Simple Pavlovian Cue-Outcome Learning Depends on Training Experience.Cerebral cortex communications · 2021Article
- Article
- Targeted Stimulation of an Orbitofrontal Network Disrupts Decisions Based on Inferred, Not Experienced Outcomes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Orbitofrontal control of visual cortex gain promotes visual associative learning.Nature communications · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Imagination, defined as the ability to interpret reality in ways that diverge from past experience, is fundamental to adaptive behavior. This can be seen at a simple level in our capacity to predict novel outcomes in new situations. The ability to anticipate outcomes never before received can also influence learning if those imagined outcomes are not received. The orbitofrontal cortex is a key candidate for where the process of imagining likely outcomes occurs; however, its precise role in generating these estimates and applying them to learning remain open questions. Here we address these questions by showing that single-unit activity in the orbitofrontal cortex reflects novel outcome estimates. The strength of these neural correlates predicted both behavior and learning, learning that was abolished by temporally specific inhibition of orbitofrontal neurons. These results are consistent with the proposal that the orbitofrontal cortex is critical for integrating information to imagine future outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.