ArticlePediatric neurology2013
Automatically quantified diffuse excessive high signal intensity on MRI predicts cognitive development in preterm infants.
Article in Pediatric neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Advanced neuroimaging and its role in predicting neurodevelopmental outcomes in very preterm infants.Seminars in perinatology · 2016Pooled it
- Diffuse white matter abnormality is independently predictive of neurodevelopmental outcomes in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Prenatal tobacco smoke exposure and risk of brain abnormalities on magnetic resonance imaging at term in infants born very preterm.American journal of obstetrics & gynecology MFM · 2023Article
- Diffuse excessive high signal intensity in the preterm brain on advanced MRI represents widespread neuropathology.NeuroImage · 2022Article
- Extracallosal Structural Connectivity Is Positively Associated With Language Performance in Well-Performing Children Born Extremely Preterm.Frontiers in pediatrics · 2022Article
- Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm.The Journal of pediatrics · 2021Article
- Automatic Segmentation of Diffuse White Matter Abnormality on T2-weighted Brain MR Images Using Deep Learning in Very Preterm Infants.Radiology. Artificial intelligence · 2021Article
- Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children.Scientific reports · 2020Article
- Objectively Diagnosed Diffuse White Matter Abnormality at Term Is an Independent Predictor of Cognitive and Language Outcomes in Infants Born Very Preterm.The Journal of pediatrics · 2020Article
- Rewiring the extremely preterm brain: Altered structural connectivity relates to language function.NeuroImage. Clinical · 2020Article
- White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposure.AJNR. American journal of neuroradiology · 2019Article
- Thirteen-Year Outcomes in Very Preterm Children Associated with Diffuse Excessive High Signal Intensity on Neonatal Magnetic Resonance Imaging.The Journal of pediatrics · 2019Observational
- Objective and Automated Detection of Diffuse White Matter Abnormality in Preterm Infants Using Deep Convolutional Neural Networks.Frontiers in neuroscience · 2019Article
- Quantitative assessment of white matter injury in preterm neonates: Association with outcomes.Neurology · 2017Article
- Differentiating T2 hyperintensity in neonatal white matter by two-compartment model of diffusional kurtosis imaging.Scientific reports · 2016Article
- Neonatal brain MRI: how reliable is the radiologist's eye?Neuroradiology · 2016Article
- Early Conventional MRI for Prediction of Neurodevelopmental Impairment in Extremely-Low-Birth-Weight Infants.Neonatology · 2016Article
- Clinical Implications of Diffuse Excessive High Signal Intensity (DEHSI) on Neonatal MRI in School Age Children Born Extremely Preterm.PloS one · 2016Article
- Diffuse excessive high signal intensity in low-risk preterm infants at term-equivalent age does not predict outcome at 1 year: a prospective study.Neuroradiology · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCognitive and language impairments constitute the majority of disabilities observed in preterm infants. It remains unclear if diffuse excessive high signal intensity on magnetic resonance imaging at term represents delayed white matter maturation or pathology.
methodsWe hypothesized that diffusion tensor imaging-based objectively quantified diffuse excessive high signal intensity measures at term will be strong predictors of cognitive and language development at 2 years in a cohort of 41 extremely low birth weight (≤1000 g) infants. Using an automated probabilistic atlas, mean diffusivity maps were used to objectively segment and quantify diffuse excessive high signal intensity volume and mean, axial, and radial diffusivity measures. Standardized neurodevelopment was assessed at 2 years of age using the Bayley Scales of Infant Development, third edition.
resultsThirty-six of the 41 infants (88%) had complete developmental data at follow-up. Objectively quantified diffuse excessive high signal intensity volume correlated significantly with cognitive and language scores at 2 years (P < 0.001 for both). The sum values of the three diffusivity measures in detected diffuse excessive high signal intensity regions also correlated significantly with the Bayley scores (r(2) 34.7%; P < 0.001 for each). Infants in the highest quartile for diffuse excessive high signal intensity volumes had scores between 19 and 24 points lower than infants in the lowest quartile (P < 0.01). When diagnosed subjectively by neuroradiologists however, Bayley scores were not significantly lower in infants with extensive diffuse excessive high signal intensity.
conclusionsThese findings lend further evidence that diffuse excessive high signal intensity is pathologic and that objectively quantified diffusion-based diffuse excessive high signal intensity volume at term is associated with cognitive and language impairments. Our approach could be used for risk stratification and early intervention for such high-risk extremely preterm infants.
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