ArticleBMC systems biology2013
Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia.
Article in BMC systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- TREM-1 Interacts with Rotavirus Proteins and Drives Inflammatory Responses: A Combined Experimental and Computational Approach.Pathogens (Basel, Switzerland) · 2025Article
- Immunology of Biliary Atresia.Seminars in pediatric surgery · 2024Review
- Liver Graft MicroRNAs Expression in Different Etiology of Acute Jaundice after Living Donor Liver Transplantation.Biology · 2022Article
- Biliary atresia: pathology, etiology and pathogenesis.Future science OA · 2020Review
- Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents.Gastroenterology · 2019Article
- A network embedding-based multiple information integration method for the MiRNA-disease association prediction.BMC bioinformatics · 2019Article
- Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies.Hepatology (Baltimore, Md.) · 2018Article
- Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease.International journal of molecular sciences · 2016Review
- Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile.Journal of visualized experiments : JoVE · 2016Article
- Serum microRNA microarray analysis identifies miR-4429 and miR-4689 are potential diagnostic biomarkers for biliary atresia.Scientific reports · 2016Article
- MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment.Journal of clinical medicine · 2015Review
- Functional and structural features of cholangiocytes in health and disease.Cellular and molecular gastroenterology and hepatology · 2015Article
- [MicroRNAs in biliary diseases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2015Article
- MicroRNAs and benign biliary tract diseases.Seminars in liver disease · 2015Review
- Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506.The Journal of biological chemistry · 2015Article
- MicroRNAs in Serum and Bile of Patients with Primary Sclerosing Cholangitis and/or Cholangiocarcinoma.PloS one · 2015Article
- MicroRNAs in Cholangiopathies.Current pathobiology reports · 2014Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBiliary atresia is a fibroinflammatory obstruction of extrahepatic bile duct that leads to end-stage liver disease in children. Despite advances in understanding the pathogenesis of biliary atresia, very little is known about the role of microRNAs (miRNAs) in onset and progression of the disease. In this study, we aimed to investigate the entire biliary transcriptome to identify miRNAs with potential role in the pathogenesis of bile duct obstruction.
resultsBy profiling the expression levels of miRNA in extrahepatic bile ducts and gallbladder (EHBDs) from a murine model of biliary atresia, we identified 14 miRNAs whose expression was suppressed at the times of duct obstruction and atresia (≥2 fold suppression, P < 0.05, FDR 5%). Next, we obtained 2,216 putative target genes of the 14 miRNAs using in silico target prediction algorithms. By integrating this result with a genome-wide gene expression analysis of the same tissue (≥2 fold increase, P < 0.05, FDR 5%), we identified 26 potential target genes with coordinate expression by the 14 miRNAs. Functional analysis of these target genes revealed a significant relevance of miR-30b/c, -133a/b, -195, -200a, -320 and -365 based on increases in expression of at least 3 target genes in the same tissue and 1st-to-3rd tier links with genes and gene-groups regulating organogenesis and immune response. These miRNAs showed higher expression in EHBDs above livers, a unique expression in cholangiocytes and the subepithelial compartment, and were downregulated in a cholangiocyte cell line after RRV infection.
conclusionsIntegrative genomics reveals functional relevance of miR-30b/c, -133a/b, -195, -200a, -320 and -365. The coordinate expression of miRNAs and target genes in a temporal-spatial fashion suggests a regulatory role of these miRNAs in pathogenesis of experimental biliary atresia.
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