ArticleBMC infectious diseases2013
Surveillance of pneumococcal serotype 1 carriage during an outbreak of serotype 1 invasive pneumococcal disease in central Australia 2010-2012.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Epidemiology ofInternational journal of molecular sciences · 2025Pooled it
- Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms.Trends in microbiology · 2022Review
- Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity.Scientific reports · 2020Article
- Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.Communications biology · 2020Article
- Associations between ethnicity, social contact, and pneumococcal carriage three years post-PCV10 in Fiji.Vaccine · 2020Article
- Estimation of the invasive disease potential of Streptococcus pneumoniae in children by the use of direct capsular typing in clinical specimens.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Molecular characterization of an Australian serotype 1 Streptococcus pneumoniae outbreak.Epidemiology and infection · 2015Article
- The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent.PloS one · 2014Article
- [Colombia need a modern national epidemiological surveillance system and to enlarge the use of molecular diagnosis in infectious diseases].Infectio : revista de la Asociacion Colombiana de InfectologiaArticle
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9 authors.
Funding
Abstract
backgroundAn outbreak of serotype 1 invasive pneumococcal disease (IPD) occurred in Central Australia from October 2010 to the latter part of 2012. Surveillance of serotype 1 carriage was conducted to determine epidemiological features of asymptomatic carriage that could potentially be driving the outbreak.
methods130 patients and accompanying persons presenting at Alice Springs Hospital Emergency Department consented to nasopharyngeal swab (NPS) collection. NPS were processed by standard methods, including culture, pneumococcal lytA quantitative real-time PCR, serotype 1-specific real-time PCR and multi-locus sequence typing (MLST).
resultsPneumococcal carriage was detected in 16% of participants. Carriage was highest in the under 10 year olds from remote communities surrounding Alice Springs (75%). Four NPS were positive for serotype 1 DNA by PCR; 3 were also culture-positive for serotype 1 pneumococci. Serotype 1 isolates had atypical colony morphology on primary culture. All serotype 1 carriers were healthy children 5 to 8 years of age from remote communities. By MLST, serotype 1 isolates were ST306, as were IPD isolates associated with this outbreak.
conclusionsDuring an outbreak of serotype 1 ST306 IPD, carriage of the outbreak strain was detected in 3% NPS collected. All carriers were healthy children 5 to 8 years of age.
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