ArticleJournal of biopharmaceutical statistics2013
Covariate imbalance and adjustment for logistic regression analysis of clinical trial data.
Article in Journal of biopharmaceutical statistics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis under imbalance in measurement of confounders in cohort studies using only summary-level data.BMC medical research methodology · 2022Pooled it
- Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in immunology · 2020Pooled it
- Ideal vs. real: a systematic review on handling covariates in randomized controlled trials.BMC medical research methodology · 2019Pooled it
- Trial
- Randomized Trial of an Intervention to Improve Blood Pressure Control in Stroke Survivors.Circulation. Cardiovascular quality and outcomes · 2019Trial
- Trial
- Covariate-Adjusted Group Sequential Comparisons of Survival Probabilities.Statistics in medicine · 2025Article
- Trends in Neuropsychiatric Terminology Use Within Registered Clinical Trials for Multiple Sclerosis: A Retrospective Descriptive Analysis.Healthcare (Basel, Switzerland) · 2025Article
- Modelling of biological age in stable and acute exacerbations of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2025Article
- Article
- Impact of Airway-Occluding Mucus Plugs on Mortality in Patients with COPD According to Disease Severity: A Subset Analysis of Data From COPDGene.International journal of chronic obstructive pulmonary disease · 2025Article
- Review
- Impact of minimal sufficient balance, minimization, and stratified permuted blocks on bias and power in the estimation of treatment effect in sequential clinical trials with a binary endpoint.Statistical methods in medical research · 2022Article
- Statistical properties of minimal sufficient balance and minimization as methods for controlling baseline covariate imbalance at the design stage of sequential clinical trials.Statistics in medicine · 2020Article
- Impact of baseline covariate imbalance on bias in treatment effect estimation in cluster randomized trials: Race as an example.Contemporary clinical trials · 2020Article
- Choosing an imbalance metric for covariate-constrained randomization in multiple-arm cluster-randomized trials.Trials · 2019Article
- Prestroke Antiplatelet Effect on Symptomatic Intracranial Hemorrhage and Functional Outcome in Intravenous Thrombolysis.Journal of stroke · 2016Article
- The impact of covariate adjustment at randomization and analysis for binary outcomes: understanding differences between superiority and noninferiority trials.Statistics in medicine · 2015Article
- Continuous covariate imbalance and conditional power for clinical trial interim analyses.Contemporary clinical trials · 2014Article
- Bias, precision and statistical power of analysis of covariance in the analysis of randomized trials with baseline imbalance: a simulation study.BMC medical research methodology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
In logistic regression analysis for binary clinical trial data, adjusted treatment effect estimates are often not equivalent to unadjusted estimates in the presence of influential covariates. This article uses simulation to quantify the benefit of covariate adjustment in logistic regression. However, International Conference on Harmonization guidelines suggest that covariate adjustment be prespecified. Unplanned adjusted analyses should be considered secondary. Results suggest that if adjustment is not possible or unplanned in a logistic setting, balance in continuous covariates can alleviate some (but never all) of the shortcomings of unadjusted analyses. The case of log binomial regression is also explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.