ArticleEpilepsia2013
Risk-taking behavior in juvenile myoclonic epilepsy.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Psychiatric Comorbidities in Pediatric Epilepsy.Current psychiatry reports · 2020Pooled it
- Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: an imaging endophenotype?Brain : a journal of neurology · 2014Trial
- SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy.NPJ genomic medicine · 2023Article
- Inhibitory control deficits in patients with mesial temporal lobe epilepsy: an event-related potential analysis based on Go/NoGo task.Frontiers in neurology · 2023Article
- Variation in prognosis and treatment outcome in juvenile myoclonic epilepsy: a Biology of Juvenile Myoclonic Epilepsy Consortium proposal for a practical definition and stratified medicine classifications.Brain communications · 2023Review
- Genetic generalized epilepsies in adults - challenging assumptions and dogmas.Nature reviews. Neurology · 2022Review
- Limited Ability to Adjust N2 Amplitude During Dual Task Walking in People With Drug-Resistant Juvenile Myoclonic Epilepsy.Frontiers in neurology · 2022Article
- Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy.Brain sciences · 2021Article
- Trait impulsivity in Juvenile Myoclonic Epilepsy.Annals of clinical and translational neurology · 2021Article
- Genetic generalized and focal epilepsy prevalence in the North American SUDEP Registry.Neurology · 2020Article
- Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.Frontiers in neurology · 2020Review
- The Timing, Nature, and Range of Neurobehavioral Comorbidities in Juvenile Myoclonic Epilepsy.Pediatric neurology · 2019Article
- Developmental MRI markers cosegregate juvenile patients with myoclonic epilepsy and their healthy siblings.Neurology · 2019Article
- Subtle Brain Developmental Abnormalities in the Pathogenesis of Juvenile Myoclonic Epilepsy.Frontiers in cellular neuroscience · 2019Review
- Risky Decision Making in Juvenile Myoclonic Epilepsy.Frontiers in neurology · 2018Article
- Sex-specific behavioral traits in the Brd2 mouse model of juvenile myoclonic epilepsy.Genes, brain, and behavior · 2014Article
- How to Advance the Debate on Nonspecific vs Specific Seizure Type and Comorbidity Profile.Epilepsy currents · 2014Article
- The challenges and innovations for therapy in children with epilepsy.Nature reviews. Neurology · 2014Review
- Mapping epileptic activity: sources or networks for the clinicians?Frontiers in neurology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivePatients with juvenile myoclonic epilepsy (JME) often present with risk-taking behavior, suggestive of frontal lobe dysfunction. Recent studies confirm functional and microstructural changes within the frontal lobes in JME. This study aimed at characterizing decision-making behavior in JME and its neuronal correlates using functional magnetic resonance imaging (fMRI).
methodsWe investigated impulsivity in 21 JME patients and 11 controls using the Iowa Gambling Task (IGT), which measures decision making under ambiguity. Performance on the IGT was correlated with activation patterns during an fMRI working memory task.
resultsBoth patients and controls learned throughout the task. Post hoc analysis revealed a greater proportion of patients with seizures than seizure-free patients having difficulties in advantageous decision making, but no difference in performance between seizure-free patients and controls. Functional imaging of working memory networks showed that overall poor IGT performance was associated with an increased activation in the dorsolateral prefrontal cortex (DLPFC) in JME patients. Impaired learning during the task and ongoing seizures were associated with bilateral medial prefrontal cortex (PFC) and presupplementary motor area, right superior frontal gyrus, and left DLPFC activation. SIGNIFICANCE: Our study provides evidence that patients with JME and ongoing seizures learn significantly less from previous experience. Interictal dysfunction within "normal" working memory networks, specifically, within the DLPFC and medial PFC structures, may affect their ability to learn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.