ArticleOncology letters2013
TIPE2 mRNA overexpression correlates with TNM staging in renal cell carcinoma tissues.
Article in Oncology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- TIPE2 serves as a favorable prognostic biomarker and suppresses cholangiocarcinoma progression by targeting RAC1-mediated integrin αvβ6 trafficking.Scientific reports · 2026Article
- A Novel Prognostic Factor TIPE2 in Bladder Cancer.Pathology oncology research : POR · 2022Article
- Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.Frontiers in immunology · 2021Article
- A novel prognostic factor TIPE2 inhibits cell proliferation and promotes apoptosis in pancreatic ductal adenocarcinoma (PDAC).International journal of medical sciences · 2021Observational
- Regulatory Roles of Tumor Necrosis Factor-α-Induced Protein 8 Like-Protein 2 in Inflammation, Immunity and Cancers: A Review.Cancer management and research · 2020Review
- Immune Negative Regulator TIPE2 Inhibits Cervical Squamous Cancer Progression Through Erk1/2 Signaling.Open life sciences · 2019Article
- Review
- Peripheral tumor necrosis factor-a-induced protein 8-like 2 mRNA level for predicting 3-month mortality of patients with acute ischemic stroke.Journal of neurology · 2018Article
- Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.BMC cancer · 2018Article
- TIPE1 suppresses invasion and migration through down-regulating Wnt/β-catenin pathway in gastric cancer.Journal of cellular and molecular medicine · 2018Article
- The decreased expression of TIPE2 protein in the decidua of patients with missed abortion and possible significance.Reproductive biology and endocrinology : RB&E · 2017Article
- Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins.Cellular & molecular immunology · 2017Review
- Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition.Cancer gene therapy · 2017Article
- TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression.Oncotarget · 2016Article
- Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling.Cancer gene therapy · 2016Article
- TIPE2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Prostate Cancer Cells by Inhibiting PI3K/Akt Signaling Pathway.Oncology research · 2016Article
- An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype.Oncotarget · 2015Article
- TIPE2 Inhibits Lung Cancer Growth Attributing to Promotion of Apoptosis by Regulating Some Apoptotic Molecules Expression.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor α-induced protein-8 like-2 (TIPE2) is a gene that maintains immune homeostasis. The aim of the present study was to determine whether TIPE2 is associated with renal cell carcinoma (RCC) progression. The mRNA expression levels of TIPE2 and myxoma resistance protein 1 (MX1; a type I interferon-inducible gene) were investigated in renal cancer tissues. A total of 46 patients who fulfilled the RCC criteria of the World Health Organization (WHO; revised in 2004) and 39 control patients with renal contusions requiring surgical extraction were enrolled. Tumor and normal renal tissues were sampled from all subjects through surgery. Total RNA was extracted and the expression of the TIPE2 and MX1 genes was evaluated by quantitative polymerase chain reaction (qPCR) analysis. TIPE2 mRNA expression was significantly upregulated in the RCC patients compared with the controls (P=0.001), while MX1 mRNA expression was decreased in the RCC patients compared with the controls (P=0.0001). Furthermore, the TIPE2 mRNA expression levels were positively correlated with TNM staging (r=0.803, P=0.001) and showed a negative correlation with the MX1 mRNA expression levels (r=-0.763, P=0.001) in the RCC patients. These results indicate that the increased expression of the TIPE2 gene is markedly associated with RCC and suggests an important role for the TIPE2 gene in the pathogenesis of RCC.
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