ArticleFrontiers in neurology2013
Sleep-dependent synaptic down-selection (I): modeling the benefits of sleep on memory consolidation and integration.
Article in Frontiers in neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Sleep and the extraction of hidden regularities: A systematic review and the importance of temporal rules.Sleep medicine reviews · 2019Pooled it
- Sleep restriction can attenuate prioritization benefits on declarative memory consolidation.Journal of sleep research · 2016Trial
- The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules.Hippocampus · 2026Article
- Sleep and Athletic Performance: A Multidimensional Review of Physiological and Molecular Mechanisms.Journal of clinical medicine · 2025Review
- Slow-wave sleep drives sleep-dependent renormalization of synaptic AMPA receptor levels in the hypothalamus.PLoS biology · 2024Article
- Article
- Consciousness and sleep.Neuron · 2024Review
- Sleep loss diminishes hippocampal reactivation and replay.Research square · 2023Article
- Remembering and forgetting in sleep: Selective synaptic plasticity during sleep driven by scaling factors Homer1a and Arc.Neurobiology of stress · 2023Article
- Article
- Multiple traces and altered signal-to-noise in systems consolidation: Evidence from the 7T fMRI Natural Scenes Dataset.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The why and how of sleep-dependent synaptic down-selection.Seminars in cell & developmental biology · 2022Article
- Integration of sleep homeostasis and navigation in Drosophila.PLoS computational biology · 2021Article
- Sleep and synaptic down-selection.The European journal of neuroscience · 2020Review
- Review
- Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.Annual review of clinical psychology · 2019Review
- Sleep Modelling across Physiological Levels.Clocks & sleep · 2019Review
- Dreaming of a learning task is associated with enhanced memory consolidation: Replication in an overnight sleep study.Journal of sleep research · 2019Article
- Principles underlying the input-dependent formation and organization of memories.Network neuroscience (Cambridge, Mass.) · 2019Article
- Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation.Cellular and molecular life sciences : CMLS · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sleep can favor the consolidation of both procedural and declarative memories, promote gist extraction, help the integration of new with old memories, and desaturate the ability to learn. It is often assumed that such beneficial effects are due to the reactivation of neural circuits in sleep to further strengthen the synapses modified during wake or transfer memories to different parts of the brain. A different possibility is that sleep may benefit memory not by further strengthening synapses, but rather by renormalizing synaptic strength to restore cellular homeostasis after net synaptic potentiation in wake. In this way, the sleep-dependent reactivation of neural circuits could result in the competitive down-selection of synapses that are activated infrequently and fit less well with the overall organization of memories. By using computer simulations, we show here that synaptic down-selection is in principle sufficient to explain the beneficial effects of sleep on the consolidation of procedural and declarative memories, on gist extraction, and on the integration of new with old memories, thereby addressing the plasticity-stability dilemma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.