ArticleFrontiers in psychology2013
Quantitative meta-analysis of fMRI and PET studies reveals consistent activation in fronto-striatal-parietal regions and cerebellum during antisaccades and prosaccades.
Article in Frontiers in psychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 6 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis.Schizophrenia research · 2024Pooled it
- Accurate localization and coactivation profiles of the frontal eye field and inferior frontal junction: an ALE and MACM fMRI meta-analysis.Brain structure & function · 2023Pooled it
- Meta-analytic evidence for downregulation of the amygdala during working memory maintenance.Human brain mapping · 2022Pooled it
- Saccadic Eye Movement in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Neuropsychology review · 2022Pooled it
- Pooled it
- A meta-analysis of functional magnetic resonance imaging studies of eye movements and visual word reading.Brain and behavior · 2017Pooled it
- GABAergic Modulation of Brain Function During Prosaccade and Antisaccade Eye Movements: Evidence From Ultra-High-Field fMRI.Human brain mapping · 2026Trial
- Cognitive deterioration and functional compensation in ALS measured with fMRI using an inhibitory task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Cortical beta power modulation is asymmetric and reduced during movement execution and inhibition in Parkinson's disease.Neurobiology of disease · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Abnormal eye movement, brain regional homogeneity in schizophrenia and clinical high-risk individuals and their associated gene expression profiles.Schizophrenia (Heidelberg, Germany) · 2025Article
- Anti-saccade can be used as a screening tool for early cognitive impairment: a correlation study based on anti-saccade parameters and cognitive function.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025Article
- Multimodal biomarker based on temporal complexity of eye movements and pupil diameter in attention-deficit/hyperactivity disorder.PLOS mental health · 2025Article
- Oculomotor functional connectivity associated with motor sequence learning.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Visuospatial, oculomotor, and executive reading skills evolve in elementary school, and errors are significant: a topological RAN study.Frontiers in psychology · 2024Article
- Potential Ocular Biomarkers for Early Detection of Alzheimer's Disease and Their Roles in Artificial Intelligence Studies.Neurology and therapy · 2023Review
- Brain FDG-PET correlates of saccadic disorders in early PSP.Journal of neurology · 2023Article
- Joint impact on attention, alertness and inhibition of lesions at a frontal white matter crossroad.Brain : a journal of neurology · 2023Article
- Exploring age-related changes in saccades during cognitive tasks in healthy adults.Frontiers in behavioral neuroscience · 2023Article
- Stimulation of non-motor subthalamic nucleus impairs selective response inhibition via prefrontal connectivity.Brain communications · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antisaccade task is a classic task of oculomotor control that requires participants to inhibit a saccade to a target and instead make a voluntary saccade to the mirror opposite location. By comparison, the prosaccade task requires participants to make a visually-guided saccade to the target. These tasks have been studied extensively using behavioral oculomotor, electrophysiological, and neuroimaging in both non-human primates and humans. In humans, the antisaccade task is under active investigation as a potential endophenotype or biomarker for multiple psychiatric and neurological disorders. A large and growing body of literature has used functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) to study the neural correlates of the antisaccade and prosaccade tasks. We present a quantitative meta-analysis of all published voxel-wise fMRI and PET studies (18) of the antisaccade task and show that consistent activation for antisaccades and prosaccades is obtained in a fronto-subcortical-parietal network encompassing frontal and supplementary eye fields (SEFs), thalamus, striatum, and intraparietal cortex. This network is strongly linked to oculomotor control and was activated to a greater extent for antisaccade than prosaccade trials. Antisaccade but not prosaccade trials additionally activated dorsolateral and ventrolateral prefrontal cortices. We also found that a number of additional regions not classically linked to oculomotor control were activated to a greater extent for antisaccade vs. prosaccade trials; these regions are often reported in antisaccade studies but rarely commented upon. While the number of studies eligible to be included in this meta-analysis was small, the results of this systematic review reveal that antisaccade and prosaccade trials consistently activate a distributed network of regions both within and outside the classic definition of the oculomotor network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.