ArticleFrontiers in behavioral neuroscience2013
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
- Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Trial
- Heart and Brain Responses to Real Versus Simulated Chess Games in Trained Chess Players: A Quantitative EEG and HRV Study.International journal of environmental research and public health · 2019Trial
- Adaptation to Stress Switches Stress-Evoked Network Disconnection to a New Forebrain Network State.eNeuro · 2026Article
- Adolescent and adult stress alter excitatory-inhibitory network dynamics in the medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Deciphering neuronal variability across states reveals dynamic sensory encoding.Nature communications · 2025Article
- Effects of Simulated Airplane Cabin Noise on In-Flight Meal Perception in the Brain Using Electroencephalography.Foods (Basel, Switzerland) · 2024Article
- Sex differences in body temperature and neural power spectra in response to repeated restraint stress.Stress (Amsterdam, Netherlands) · 2024Article
- Influence of chronic stress on network states governing valence processing: Potential relevance to the risk for psychiatric illnesses.Journal of neuroendocrinology · 2023Review
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture.iScience · 2023Article
- Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Decreased phase information transfer from the mPFC to the BLA: During exploratory behavior in CUMS rats.Frontiers in neuroscience · 2023Article
- Sex differences in amygdalohippocampal oscillations and neuronal activation in a rodent anxiety model and in response to infralimbic deep brain stimulation.Frontiers in behavioral neuroscience · 2023Article
- The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.Nature communications · 2022Article
- Controllable and Uncontrollable Stress Differentially Impact Fear Conditioned Alterations in Sleep and Neuroimmune Signaling in Mice.Life (Basel, Switzerland) · 2022Article
- Edge-based network analysis reveals frequency-specific network dynamics in aberrant anxiogenic processing in rats.Network neuroscience (Cambridge, Mass.) · 2022Article
- Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Stress enhances emotional memory-related theta oscillations in the medial temporal lobe.Neurobiology of stress · 2021Article
- Modulation of recognition memory performance by light and its relationship with cortical EEG theta and gamma activities.Biochemical pharmacology · 2021Article
- Anxiety and Alzheimer's disease: Behavioral analysis and neural basis in rodent models of Alzheimer's-related neuropathology.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials (LFP) were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC, respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.
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