ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Astrocyte elevated gene-1 is a novel biomarker of epithelial-mesenchymal transition and progression of hepatocellular carcinoma in two China regions.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression.Journal of cellular and molecular medicine · 2017Article
- Metadherin regulates epithelial-mesenchymal transition in carcinoma.OncoTargets and therapy · 2016Review
- A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Astrocyte elevated gene-1 overexpression in hepatocellular carcinoma: an independent prognostic factor.Annals of surgical treatment and research · 2015Article
- Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.International journal of clinical and experimental medicine · 2015Article
- Association of androgen receptor exon 1 CAG repeat length with risk of hepatocellular carcinoma: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- TGF-β1 mediates estrogen receptor-induced epithelial-to-mesenchymal transition in some tumor lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Genetic variations of CAV1 gene contribute to HCC risk: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Astrocyte elevated gene-1: a novel independent prognostic biomarker for metastatic ovarian tumors.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- AU-binding factor 1 expression was correlated with metadherin expression and progression of hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
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10 authors.
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Abstract
Astrocyte elevated gene-1 (AEG-1) is involved in important biological processes including cell invasion, metastasis, and carcinogenesis. However, its clinical significance has remained largely unknown in hepatocellular carcinoma. Here, specimens from 144 patients with hepatocellular carcinomas in Beijing and Heilongjiang regions were investigated by immunohistochemical staining for AEG-1, vimentin, and E-cadherin expressions. A clinicopathological study revealed that AEG-1 expression level in tumor cells was significantly correlated with TNM stage (P = 0.001) and Edmonson grade (P < 0.0001). In addition, AEG-1, vimentin, and E-cadherin (epithelial-mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that AEG-1 may be an epithelial-mesenchymal transition-associated biomarker in human hepatocellular carcinoma and play important roles in the progression of hepatocellular carcinoma. In addition, the AEG-1 gene is a potential target for elimination of hepatocellular carcinoma in the future.
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