ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Pooled it
- A risk of digestive tract neoplasms susceptibility in miR-146a and miR-196a2.Familial cancer · 2015Pooled it
- Quantitative Assessment of the Association between Genetic Variants in MicroRNAs and Colorectal Cancer Risk.BioMed research international · 2015Pooled it
- Meta-analysis of Hsa-mir-499 polymorphism (rs3746444) for cancer risk: evidence from 31 case-control studies.BMC medical genetics · 2014Pooled it
- Review
- Functional Variants in MicroRNAs (rs895819, rs11614913 and rs2910164) Are Associated with Susceptibility and Clinicopathological Features in Mexican Patients with Colorectal Cancer.Archives of Iranian medicine · 2023Article
- Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population.Cancer biomarkers : section A of Disease markers · 2023Article
- Curcumin Targeting Non-Coding RNAs in Colorectal Cancer: Therapeutic and Biomarker Implications.Biomolecules · 2022Review
- Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis.Biomedicines · 2022Review
- Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis.Scientific reports · 2021Article
- Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese.International journal of medical sciences · 2020Article
- Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population.Cancer medicine · 2018Article
- A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies.Frontiers in physiology · 2018Article
- Role of MicroRNA-93 I in Pathogenesis of Left Ventricular Remodeling via Targeting Cyclin-D1.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- MicroRNA gene polymorphisms and the risk of colorectal cancer.Oncology letters · 2017Article
- Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs.PloS one · 2017Article
- Genetic variationOncoTargets and therapy · 2016Article
- MicroRNA-93 suppress colorectal cancer development via Wnt/β-catenin pathway downregulating.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- The association between miR-499 polymorphism and cancer susceptibility: a meta-analysis.OncoTargets and therapy · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) play an important role in the pathogenesis of neoplasm. Single nucleotide polymorphisms (SNPs) within miRNAs can change their phenotype and function. We attempted to analyze the relationship between two SNP loci in miRNAs and colorectal cancer (CRC) in Chinese Han population. We genotyped the polymorphism of two common miRNA SNPs, miR-146a (rs2910164 G > C) and miR-499 (rs3746444 T > C), in a case-control study of 276 CRC cases and 373 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotypes and allele frequencies of the two SNP loci were first compared between patients and controls and then further analyzed among subgroups of patients with different clinicopathological profiles. The rs2910164 CG genotype was significantly associated with a decreased risk of CRC [CG versus GG, odds ratio (OR) = 0.567; 95% confidence intervals (CIs) = 0.338-0.952; p = 0.031]. No significant differences of miR-499 genotype and allele distribution were detected between patients and controls. Comparison between groups divided by clinicopathologic features showed that the polymorphism of miR-146a was associated with the degree of tumor differentiation (p = 0.014), and the G allele of rs2910164 trended to a mature differentiation (OR = 0.553; 95% CI = 0.315-0.971; p = 0.038). MiR-146a (rs2910164 G > C) polymorphism is associated with CRC susceptibility and histological differentiation in Chinese Han population.
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