Trial reportAge (Dordrecht, Netherlands)2014
Explosive type of moderate-resistance training induces functional, cardiovascular, and molecular adaptations in the elderly.
Trial report in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effects of exercise on different antioxidant enzymes and related indicators: a systematic review and meta-analysis of randomized controlled trials.Scientific reports · 2025Pooled it
- Does High-Velocity Resistance Exercise Elicit Greater Physical Function Benefits Than Traditional Resistance Exercise in Older Adults? A Systematic Review and Network Meta-Analysis of 79 Trials.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Pooled it
- Exercise for reducing falls in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018Pooled it
- The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Ageing, Muscle Power and Physical Function: A Systematic Review and Implications for Pragmatic Training Interventions.Sports medicine (Auckland, N.Z.) · 2016Pooled it
- Resistance-based training improves mitochondrial capacity and redox balance in aging adults, independent of polyphenol supplementation.Redox biology · 2026Trial
- Muscular HSP70 content is higher in elderly compared to young, but is normalized after 12 weeks of strength training.European journal of applied physiology · 2021Trial
- Comparison of the acute effects of traditional versus high velocity resistance training on metabolic, cardiovascular, and psychophysiological responses in elderly hypertensive women.Clinical interventions in aging · 2018Trial
- Short-term, supra-physiological rhGH administration induces transient DNA damage in peripheral lymphocytes of healthy women.Journal of endocrinological investigation · 2017Trial
- Oxidative stress responses to a graded maximal exercise test in older adults following explosive-type resistance training.Redox biology · 2014Trial
- Therapeutic Potential of Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles in Atherosclerotic Stenosis and Endothelial Dysfunction.Cardiovascular drugs and therapy · 2026Article
- Resistance training effects on gait parameters in older adults-a systematic review with multilevel meta-analysis and meta-regression.GeroScience · 2026Review
- Exercise attenuates stress-related signaling as sensed by higher phosphorylation of small heat shock proteins in skeletal muscle from older individuals.Journal of sport and health science · 2025Article
- Effects of resistance training on heat shock response (HSR), HSP70 expression, oxidative stress, inflammation, and metabolism in middle-aged people.Journal of physiology and biochemistry · 2024Article
- The effect of eight-week resistance training on oxidative stress in isoproterenol-induced myocardial infarction in rats.Archives of medical sciences. Atherosclerotic diseases · 2024Article
- Online Home-Based Physical Activity Counteracts Changes of Redox-Status Biomarkers and Fitness Profiles during Treatment Programs in Postsurgery Female Breast Cancer Patients.Antioxidants (Basel, Switzerland) · 2023Article
- Aging, Physical Exercise, Telomeres, and Sarcopenia: A Narrative Review.Biomedicines · 2023Review
- Long-term exercise training and inflammatory biomarkers in healthy subjects: a meta-analysis of randomized controlled trials.Frontiers in psychology · 2023Review
- Exercise Training and Skeletal Muscle Antioxidant Enzymes: An Update.Antioxidants (Basel, Switzerland) · 2022Review
- The Preventive Role of Physical Activity in Systemic Sclerosis: A Cross-Sectional Study on the Correlation with Clinical Parameters and Disease Progression.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current recommendations aimed at reducing neuromuscular and functional loss in aged muscle have identified muscle power as a key target for intervention trials, although little is known about the biological and cardiovascular systemic response in the elderly. This study investigated the effects of 12 weeks of low-frequency, moderate-intensity, explosive-type resistance training (EMRT) on muscle strength and power in old community-dwelling people (70-75 years), monitoring functional performance linked to daily living activities (ADL) and cardiovascular response, as well as biomarkers of muscle damage, cardiovascular risk, and cellular stress response. The present study provides the first evidence that EMRT was highly effective in achieving a significant enhancement in muscular strength and power as well as in functional performance without causing any detrimental modification in cardiovascular, inflammatory, and damage parameters. Moreover, trained elderly subjects showed an adaptive response at both systemic and cellular levels by modulation of antioxidant and stress-induced markers such as myeloperoxidase (MPO), heat shock protein 70 (Hsp70) and 27 (Hsp27), and thioredoxin reductase 1 (TrxR1).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.