SynthesisBMJ (Clinical research ed.)2013
Non-invasive versus invasive respiratory support in preterm infants at birth: systematic review and meta-analysis.
Synthesis in BMJ (Clinical research ed.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 195 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Novel Training Simulator for Portable Ultrasound Identification of Incorrect Newborn Endotracheal Tube Placement, Karachi Pakistan
Enteral Nutrition Tolerance and Non-invasive Respiratory Support in Preterm Infants
Who cites it
195 citing papers in PubMed, 13 syntheses or guidelines pooled it, 532 citations in OpenAlex.
- Meta-analysis of nasal interfaces versus face mask during respiratory support at birth in less than 37 weeks' gestation infants.Pediatric research · 2026Pooled it
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.Clinical and experimental emergency medicine · 2026Guideline
- Non-invasive respiratory support in preterm infants as primary mode: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- NIV-NAVA versus non-invasive respiratory support in preterm neonates: a meta-analysis of randomized controlled trials.Journal of perinatology : official journal of the California Perinatal Association · 2024Pooled it
- Peri-extubation settings in preterm neonates: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2024Pooled it
- Nasal continuous positive airway pressure levels for the prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Lung Ultrasound for the Diagnosis of Neonatal Respiratory Distress Syndrome: A Meta-analysis.Ultrasound quarterly · 2020Pooled it
- Positive end-expiratory pressure for preterm infants requiring conventional mechanical ventilation for respiratory distress syndrome or bronchopulmonary dysplasia.The Cochrane database of systematic reviews · 2019Pooled it
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2019 Update.Neonatology · 2019Guideline
- Sustained inflations and avoiding mechanical ventilation to prevent death or bronchopulmonary dysplasia: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2018Pooled it
- Surfactant instillation in spontaneously breathing preterm infants: a systematic review and meta-analysis.European journal of pediatrics · 2016Pooled it
- Protocolized versus non-protocolized weaning for reducing the duration of invasive mechanical ventilation in newborn infants.The Cochrane database of systematic reviews · 2016Pooled it
- Do newborn infants exhale through the CPAP system? Secondary analysis of a randomised cross-over trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Use of ventilation/perfusion mismatch to guide individualised CPAP level selection in preterm infants: a feasibility trial.Archives of disease in childhood. Fetal and neonatal edition · 2023Trial
- Regular lung recruitment maneuvers during high-frequency oscillatory ventilation in extremely preterm infants: a randomized controlled trial.BMC pediatrics · 2022Trial
- Trial
- Non-invasive duo positive airway pressure ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: a randomized controlled trial.BMC pediatrics · 2021Trial
- [Safety of two ventilator weaning strategies after high-frequency oscillatory ventilation in preterm infants with respiratory distress syndrome: a prospective randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
- [Clinical effect of an additional maintenance dose of caffeine before ventilator weaning in preterm infants with respiratory distress syndrome: a prospective randomized controlled trial].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Trial
135 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the role of nasal continuous positive airway pressure (CPAP) initiated at birth for prevention of death and bronchopulmonary dysplasia in very preterm infants.
designSystematic review. DATA SOURCES: PubMed, Embase, the Cochrane Central Register of Controlled Trials, and online Pediatric Academic Society abstracts from the year of inception to June 2013. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials evaluating the effect of nasal CPAP compared with intubation in preterm infants born at less than 32 weeks' gestation and presenting the outcomes of either death or bronchopulmonary dysplasia, or both (defined as the need for oxygen support or mechanical ventilation at 36 weeks corrected gestation), during hospital stay.
resultsFour randomised controlled trials (2782 participants) met the inclusion criteria, with 1296 infants in the nasal CPAP group and 1486 in the intubation group. All the trials reported bronchopulmonary dysplasia independently at 36 weeks corrected gestation, with borderline significance in favour of the nasal CPAP group (relative risk 0.84, 95% confidence interval 0.68 to 1.04, risk difference -0.02, 95% confidence interval -0.04 to 0.01). [corrected] No difference in death was observed (relative risk 0.88, 0.68 to 1.14, risk difference -0.02, -0.04 to 0.01, respectively). Pooled analysis showed a significant benefit for the combined outcome of death or bronchopulmonary dysplasia, or both, at 36 weeks corrected gestation for babies treated with nasal CPAP (relative risk 0.90 (95% confidence interval 0.83 to 0.98, risk difference -0.04 (95% confidence interval -0.08 to -0.00), NNT [corrected] of 25).
conclusionOne additional infant could survive to 36 weeks without bronchopulmonary dysplasia for every 25 babies treated with nasal CPAP in the delivery room rather than being intubated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.