Evidence map›Paper›PMID 24136455›Full record

ReviewCurrent neurology and neuroscience reports2013

Chronic traumatic encephalopathy: where are we and where are we going?

Jesse Mez, Robert A Stern, Ann C McKee

Abstract readReview
In one paragraph

Review in Current neurology and neuroscience reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Retired National Football League Players are Not at Greater Risk for Suicide.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2020
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. A Novel Method to Model Chronic Traumatic Encephalopathy in Drosophila.Journal of visualized experiments : JoVE · 2017
    Article
  17. Article
  18. Article
  19. Chronic Traumatic Encephalopathy in Athletes Involved with High-impact Sports.Journal of vascular and interventional neurology · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jesse MezBoston University Alzheimer's Disease Center, Boston University School of Medicine, 72 E. Concord Street, Suite 7800, Boston, MA, 02118, USA, jessemez@bu.edu.
Robert A Stern
Ann C McKee

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
Chronic Traumatic Encephalopathy: Clinical Presentation and BiomarkersR01NS078337 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STERN, ROBERT A · 2011 to 2013
$2.0M
NIA NIH HHS P30 AG013846NIA NIH HHS P30AG13846NINDS NIH HHS 5T32NS007153-27NINDS NIH HHS R01 NS078337NINDS NIH HHS T32 NS007153
6 · The paper itself

Abstract

Chronic traumatic encephalopathy (CTE, previously called punch drunk and dementia pugilistica) has a rich history in the medical literature in association with boxing, but has only recently been recognized with other contact sports, such as football and ice hockey, as well as with military blast injuries. CTE is thought to be a neurodegenerative disease associated with repeated concussive and subconcussive blows to the head. There is characteristic gross and microscopic pathology found in the brain, including frontal and temporal atrophy, axonal degeneration, and hyperphosphorylated tau and TAR DNA-binding protein 43 pathology. Clinically, there are characteristic progressive deficits in cognition (memory, executive dysfunction), behavior (explosivity, aggression), mood (depression, suicidality), and motor function (parkinsonism), which correlate with the anatomic distribution of brain pathology. While CTE shares clinical and neuropathological traits with other neurodegenerative diseases, the clinical syndrome and the neuropathology as a whole are distinct from other neurodegenerative diseases. Here we review the CTE literature to date. We also draw on the literature from mild traumatic brain injury and other neurodegenerative dementias, particularly when these studies provide guidance for future CTE research. We conclude by suggesting seven essential areas for future CTE research.

Indexed as

AnimalsBiomarkersBoxingBrain Injury, ChronicHumansMagnetic Resonance ImagingNeuroimagingNeuropsychological TestsPositron-Emission TomographyTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedBiomarkers

Identifiers

PMID24136455
PMCPMC4550089

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.