ArticleInternational journal of behavioral medicine2014
Association between lipid profile and depressive symptoms among Chinese older people: mediation by cardiovascular diseases?
Article in International journal of behavioral medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Depression and serum low-density lipoprotein: A systematic review and meta-analysis.Journal of affective disorders · 2016Pooled it
- Lipid metabolism dysregulation in late-life depression: peripheral metabolic disturbance, central lipid alterations, and dietary modulation.Frontiers in nutrition · 2026Review
- Multitrait Genetic Analysis Identifies Novel Pleiotropic Loci for Depression and Schizophrenia in East Asians.Schizophrenia bulletin · 2025Article
- Sleep duration and cognitive function among rural older adults in China: A population-based study.PloS one · 2025Article
- Factor Structures in the Depressive Symptoms Domains in the 9Q for Northern Thai Adults and Their Association with Chronic Diseases.Behavioral sciences (Basel, Switzerland) · 2024Article
- The role of lipoprotein profile in depression and cognitive performance: a network analysis.Scientific reports · 2020Article
- Depressive Symptoms are Associated with High Levels of Serum Low-Density Lipoprotein Cholesterol in Older Adults with Type 2 Diabetes Mellitus.Arquivos brasileiros de cardiologia · 2020Article
- Areca nut chewing is associated with common mental disorders: a population-based study.Social psychiatry and psychiatric epidemiology · 2018Article
- Longitudinal study of low serum LDL cholesterol and depressive symptom onset in postmenopause.The Journal of clinical psychiatry · 2016Article
- Article
- Total serum cholesterol, atherogenic indices and their longitudinal association with depressive symptoms among US adults.Translational psychiatry · 2015Article
- Prevalence and Patterns of Chronic Disease Pairs and Multimorbidity among Older Chinese Adults Living in a Rural Area.PloS one · 2015Article
- Prevalence of dyslipidemia and its association with insomnia in a community based population in China.BMC public health · 2014Article
- Depression in silent lacunar infarction: a cross-sectional study of its association with location of silent lacunar infarction and vascular risk factors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Behavioral medicine in China.International journal of behavioral medicine · 2014Article
- The Importance of Cholesterol in Psychopathology: A Review of Recent Contributions.Indian journal of psychological medicineReview
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe potential mediating effect of cardiovascular diseases (CVDs) (e.g., ischemic heart disease and stroke) on the association between abnormal serum lipids and late-life depressive symptoms has not been investigated. PURPOSE: We aimed to examine the associations between serum lipids and elevated depressive symptoms among older Chinese people and to determine the extent to which CVDs mediate their associations.
methodThis cross-sectional study included 1,529 participants (age ≥60 years, 59.2% women) in the Confucius Hometown Aging Project. In June 2010-July 2011, data were collected through an interview, clinical examinations, and laboratory tests. Abnormal serum lipids were defined according to international criteria and use of hypolipidemic drugs. Presence of elevated depressive symptoms was defined as the 15-item Geriatric Depression Scale score ≥5. Data were analyzed with logistic and mediation models controlling for potential confounders.
resultsThe prevalence of depressive symptoms was 20.3%. Depressive symptomatology was significantly associated with high total cholesterol, high triglycerides, low high-density lipoprotein cholesterol (HDL-C), high low-density lipoprotein cholesterol (LDL-C), and dyslipidemia (p < 0.05). The mediating effects on the associations of serum lipids with depressive symptoms were statistically significant for ischemic heart disease and stroke with the proportion of mediating effects over the total effects ranging 4.7-7.0% and 7.3-12.1%, respectively.
conclusionElevated depressive symptoms are associated with lipid profile characterized by high cholesterol, high triglycerides, low HDL-C, high LDL-C, and dyslipidemia; the associations are partially mediated by ischemic heart disease and stroke. These findings imply that unfavorable lipid profile may be involved in late-life depressive symptoms independent of atherosclerotic disorders.
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