ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Species-conserved reconfigurations of brain network topology induced by ketamine.Translational psychiatry · 2016Trial
- High-dose medetomidine increases functional connectivity in the fear-related regions after electrical stimulation.Scientific reports · 2025Article
- Prophylactic (R,S)-Ketamine and (2S,6S)-Hydroxynorketamine Decrease Fear Expression by Differentially Modulating Fear Neural Ensembles.Biological psychiatry · 2025Article
- Propofol disrupts alpha dynamics in functionally distinct thalamocortical networks during loss of consciousness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dose-dependent effects of esketamine on brain activity in awake mice: A BOLD phMRI study.Pharmacology research & perspectives · 2022Article
- Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits.Molecular psychiatry · 2022Article
- Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat: an MRI and immuno-labeling study.Brain structure & function · 2021Article
- Human hippocampal connectivity is stronger in olfaction than other sensory systems.Progress in neurobiology · 2021Article
- Systematic Review: Anesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part B: Effects of Anesthetic Agents, Doses and Timing.Animals : an open access journal from MDPI · 2021Review
- Ketamine promotes the neural differentiation of mouse embryonic stem cells by activating mTOR.Molecular medicine reports · 2020Article
- Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.Cell proliferation · 2020Review
- Ketamine in Major Depressive Disorder: Mechanisms and Future Perspectives.Psychiatry investigation · 2020Article
- NMDA receptor antagonists traxoprodil and lanicemine improve hippocampal-prefrontal coupling and reward-related networks in rats.Psychopharmacology · 2019Article
- Differences between ketamine's short-term and long-term effects on brain circuitry in depression.Translational psychiatry · 2019Article
- "Special K" Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments.Oxidative medicine and cellular longevity · 2019Article
- Eradicating Suicide at Its Roots: Preclinical Bases and Clinical Evidence of the Efficacy of Ketamine in the Treatment of Suicidal Behaviors.International journal of molecular sciences · 2018Review
- Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression.Translational psychiatry · 2018Article
- The role of fMRI in drug development.Drug discovery today · 2018Review
- Depression in chronic ketamine users: Sex differences and neural bases.Psychiatry research. Neuroimaging · 2017Article
Corrections and comments
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9 authors.
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Abstract
Dysfunctional connectivity within the hippocampal-prefrontal circuit (HC-PFC) is associated with schizophrenia, major depression, and neurodegenerative disorders, and both the hippocampus and prefrontal cortex have dense populations of N-methyl-D-aspartate (NMDA) receptors. Ketamine, a potent NMDA receptor antagonist, is of substantial current interest as a mechanistic model of glutamatergic dysfunction in animal and human studies, a psychotomimetic agent and a rapidly acting antidepressant. In this study, we sought to understand the modulatory effect of acute ketamine administration on functional connectivity in the HC-PFC system of the rat brain using resting-state fMRI. Sprague-Dawley rats in four parallel groups (N=9 per group) received either saline or one of three behaviorally relevant, sub-anesthetic doses of S-ketamine (5, 10, and 25 mg/kg, s.c.), and connectivity changes 15- and 30-min post-injection were studied. The strongest effects were dose- and exposure-dependent increases in functional connectivity within the prefrontal cortex and in anterior-posterior connections between the posterior hippocampus and retrosplenial cortex, and prefrontal regions. The increased prefrontal connectivity is consistent with ketamine-induced increases in HC-PFC electroencephalographic gamma band power, possibly reflecting a psychotomimetic aspect of ketamine's effect, and is contrary to the data from chronic schizophrenic patients suggesting that ketamine effect does not necessarily parallel the disease pattern but might rather reflect a hyperglutamatergic state. These findings may help to clarify the brain systems underlying different dose-dependent behavioral profiles of ketamine in the rat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.