ArticleInternational urology and nephrology2014
The Prostate Health Index in predicting initial prostate biopsy outcomes in Asian men with prostate-specific antigen levels of 4-10 ng/mL.
Article in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comprehensive Assessment of the Physical and Biological Effects of Patients With Prostate Cancer in Hong Kong
The Investigation of New Biological Markers for Prostate Cancer Diagnosis and Management in Chinese Population
Artificial Intelligence (AI)-Assisted Risk-based Prostate Cancer Detection: A Synergy of Novel Biomarkers, Advanced Imaging, and Robotic-assisted Diagnosis
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical use of [-2]proPSA (p2PSA) and its derivatives (%p2PSA and Prostate Health Index) for the detection of prostate cancer: a review of the literature.Korean journal of urology · 2014Pooled it
- Diagnostic ability of %p2PSA and prostate health index for aggressive prostate cancer: a meta-analysis.Scientific reports · 2014Pooled it
- A 2-year prospective evaluation of the Prostate Health Index in guiding biopsy decisions in a large cohort.BJU international · 2025Article
- Prostate health index (PHI) as an accurate prostate cancer predictor.Journal of cancer research and clinical oncology · 2023Observational
- Performance of Prostate Health Index in Biopsy Naïve Black Men.The Journal of urology · 2021Article
- Diagnostic accuracy of Raman spectroscopy for prostate cancer: a systematic review and meta-analysis.Translational andrology and urology · 2021Article
- Explication of the roles of prostate health index (PHI) and urokinase plasminogen activator (uPA) as diagnostic and predictor tools for prostate cancer in equivocal PSA range of 4-10 ng/mL.Saudi journal of biological sciences · 2020Article
- Prostate health index density predicts aggressive pathological outcomes after radical prostatectomy in Taiwanese patients.Journal of the Chinese Medical Association : JCMA · 2019Article
- Evaluation of neurotensin receptor 1 as potential biomarker for prostate cancer theranostic use.European journal of nuclear medicine and molecular imaging · 2019Article
- Assessment of men's risk thresholds to proceed with prostate biopsy for the early detection of prostate cancer.International urology and nephrology · 2019Article
- Consensus statements on the management of clinically localized prostate cancer from the Hong Kong Urological Association and the Hong Kong Society of Uro-Oncology.BJU international · 2019Review
- The impact of pre-existing cancer on survival of prostate cancer patients: A population-based study.Medicine · 2018Article
- Prospective performance of the Prostate Health Index in prostate cancer detection in the first prostate biopsy of men with a total prostatic specific antigen of 4-10 ng/mL and negative digital rectal examination.Prostate international · 2018Article
- Prostate Health Index (PHI) improves prostate cancer detection at initial biopsy in Taiwanese men with PSA 4-10 ng/mL.The Kaohsiung journal of medical sciences · 2018Article
- Diagnostic Performance of %[-2]proPSA and Prostate Health Index for Prostate Cancer: Prospective, Multi-institutional Study.Journal of Korean medical science · 2018Article
- Prostate cancer screening in Europe and Asia.Asian journal of urology · 2017Review
- Adaptation and external validation of the European randomised study of screening for prostate cancer risk calculator for the Chinese population.Prostate cancer and prostatic diseases · 2017Article
- Prostate health index (PHI) and prostate-specific antigen (PSA) predictive models for prostate cancer in the Chinese population and the role of digital rectal examination-estimated prostate volume.International urology and nephrology · 2016Article
- Extended use of Prostate Health Index and percentage of [-2]pro-prostate-specific antigen in Chinese men with prostate specific antigen 10-20 ng/mL and normal digital rectal examination.Investigative and clinical urology · 2016Article
- Clinical Utility of Biomarkers in Localized Prostate Cancer.Current oncology reports · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the role of the Prostate Health Index (phi) in prostate cancer (PCa) detection in patients with a prostate-specific antigen (PSA) level of 4-10 ng/mL receiving their first prostatic biopsy in an Asian population.
methodsThis was a retrospective study of archived serum samples from patients enlisted in our tissue bank. Patients over 50 years old, with PSA level of 4-10 ng/mL, a negative digital rectal examination, and received their first prostatic biopsy between April 2008 and April 2013, were recruited. The serum sample collected before biopsy was retrieved for the measurement of various PSA derivatives and the phi value was calculated for each patient. The performance of these parameters in predicting the prostatic biopsy results was assessed.
resultsTwo hundred and thirty consecutive patients, with 21 (9.13 %) diagnosed with PCa, were recruited for this study. Statistically significant differences between PCa patients and non-PCa patients were found for total PSA, PSA density, [-2]proPSA (p2PSA), free-to-total PSA ratio (%fPSA), p2PSA-to-free PSA ratio (%p2PSA), and phi. The areas under the curve of the receiver operating characteristic curve for total PSA, PSA density, %fPSA, %p2PSA, and phi were 0.547, 0.634, 0.654, 0.768, and 0.781, respectively. The phi was the best predictor of the prostatic biopsies results. At a sensitivity of 90 %, the use of the phi could have avoided unnecessary biopsies in 104 (45.2 %) patients.
conclusionsUse of the phi could improve the accuracy of PCa detection in patients with an elevated PSA level and thus avoid unnecessary prostatic biopsies.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.