Evidence map›Paper›PMID 24136128›Full record

ReviewCurrent opinion in neurology2013

Stem cell therapy for acute cerebral injury: what do we know and what will the future bring?

Robin Lemmens, Gary K Steinberg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 55 citations in OpenAlex.

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  14. Combined acupuncture andNeural regeneration research · 2018
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  20. Adult human dental pulp stem cells promote blood-brain barrier permeability through vascular endothelial growth factor-a expression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Robin LemmensaLaboratory of Neurobiology, Vesalius Research Center, VIB bExperimental Neurology and Leuven Research Institute for Neurodegenerative Diseases (LIND), University of Leuven cDepartment of Neurology, University Hospitals Leuven, Leuven, Belgium dDepartment of Neurosurgery, Stanford Stroke Center, and Stanford Institute for Neuro-Innovation & Translational Neurosciences, Stanford University School of Medicine, Stanford, California, USA.
Gary K Steinberg
GTx (United States) · USStanford University · US

Funding

Paracrine and synaptic mechanisms underlying recovery using human stem cell theraR01NS058784 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2008 to 2023
$6.6M
NINDS NIH HHS 2R01NS058784NINDS NIH HHS R01 NS058784
6 · The paper itself

Abstract

purpose of reviewThe central nervous system has limited capacity for regeneration after acute and chronic injury. An attractive approach to stimulate neural plasticity in the brain is to transplant stem cells in order to restore function. Here, we discuss potential mechanisms of action, current knowledge and future perspectives of clinical stem cell research for stroke and traumatic brain injury. RECENT

findingsPreclinical data using various models suggest stem cell therapy to be a promising therapeutic avenue. Progress has been made in elucidating the mechanism of action of various cell types used, shifting the hypothesis from neural replacement to enhancing endogenous repair processes. Translation of these findings in clinical trials is currently being pursued with emphasis on both safety as well as efficacy. SUMMARY: Clinical trials are currently recruiting patients in phase I and II trials to gain more insight in the therapeutic potential of stem cells in acute cerebral injury. A close interplay between results of these clinical trials and more extensive basic research is essential for future trial design, choosing the optimal transplantation strategy and selecting the right patients.

Indexed as

Brain InjuriesHumansStem CellsStem Cell Transplantation

Identifiers

PMID24136128
PMCPMC4465754
OpenAlexW2325155086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.