ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
A cross-validation of near-infrared spectroscopy measurements of skeletal muscle oxidative capacity with phosphorus magnetic resonance spectroscopy.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 108 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus
Open the trial in the graphComparison of Clinical and Physiological Response Among Three Modalities of Exercise Training in COPD With Chronic Respiratory Failure (CRF)
Who cites it
108 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Muscle Oximetry in Sports Science: An Updated Systematic Review.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor-A Systematic Review.Neural plasticity · 2019Pooled it
- Leg fidgeting alleviates reduced oxygen extraction in the gastrocnemius muscle caused by prolonged sitting: a randomized crossover trial.European journal of applied physiology · 2025Trial
- Trial
- The effects of normobaric and hypobaric hypoxia on cognitive performance and physiological responses: A crossover study.PloS one · 2022Trial
- Muscle mitochondrial capacity in high- and low-fitness females using near-infrared spectroscopy.Physiological reports · 2021Trial
- The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study.Nitric oxide : biology and chemistry · 2021Trial
- Partial-body cryotherapy (-135°C) and cold-water immersion (10°C) after muscle damage in females.Scandinavian journal of medicine & science in sports · 2020Trial
- Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction.Circulation research · 2017Trial
- Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction.Circulation · 2015 · on this mapTrial
- Near infrared spectroscopy-derived muscle oxidative capacity correlates to oxidative metabolic predictors of performance in highly trained female middle-distance runners.Physiological reports · 2026Article
- Preserved muscle oxidative capacity in COPD patients with hypoxemia treated by long term OEuropean journal of applied physiology · 2026Article
- The impact of muscle oxidative capacity on neuromuscular recovery after exercise-induced muscle damage.European journal of applied physiology · 2026Article
- Validation of muscle oxygenation kinetics to predict aerobic fitness and exercise transition thresholds.Experimental physiology · 2026Article
- Steepest near-infrared spectroscopy-derived deoxygenation slopes during arterial occlusions provide more reliable assessments of muscle mitochondrial capacity.Experimental physiology · 2026Article
- Change in mitochondrial capacity in elite triathletes, cyclists, and wrestlers over a training period of 28 days.European journal of applied physiology · 2026Article
- Measuring Muscle Post-Exercise Oxygen Consumption in Individuals with a Family History of Diabetes.Journal of functional morphology and kinesiology · 2026Article
- Oxidative and OExperimental physiology · 2025Article
- Effects of Compression Garments on Muscle Oxygen Saturation Recovery in the Upper Limbs Using Near-Infrared Spectroscopy.Journal of functional morphology and kinesiology · 2025Article
- Muscle oxidative capacity but not specific force is greater in aerobic versus resistance trained young adults.European journal of applied physiology · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The purpose of this study was to cross-validate measurements of skeletal muscle oxidative capacity made with near-infrared spectroscopy (NIRS) measurements to those made with phosphorus magnetic resonance spectroscopy ((31)P-MRS). Sixteen young (age = 22.5 ± 3.0 yr), healthy individuals were tested with both (31)P-MRS and NIRS during a single testing session. The recovery rate of phosphocreatine was measured inside the bore of a 3-Tesla MRI scanner, after short-duration (∼10 s) plantar flexion exercise as an index of skeletal muscle oxidative capacity. Using NIRS, the recovery rate of muscle oxygen consumption was also measured using repeated, transient arterial occlusions outside the MRI scanner, after short-duration (∼10 s) plantar flexion exercise as another index of skeletal muscle oxidative capacity. The average recovery time constant was 31.5 ± 8.5 s for phosphocreatine and 31.5 ± 8.9 s for muscle oxygen consumption for all participants (P = 0.709). (31)P-MRS time constants correlated well with NIRS time constants for both channel 1 (Pearson's r = 0.88, P < 0.0001) and channel 2 (Pearson's r = 0.95, P < 0.0001). Furthermore, both (31)P-MRS and NIRS exhibit good repeatability between trials (coefficient of variation = 8.1, 6.9, and 7.9% for NIRS channel 1, NIRS channel 2, and (31)P-MRS, respectively). The good agreement between NIRS and (31)P-MRS indexes of skeletal muscle oxidative capacity suggest that NIRS is a valid method for assessing mitochondrial function, and that direct comparisons between NIRS and (31)P-MRS measurements may be possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.