Observational studyWorld journal of urology2014
Lower urinary tract symptoms improve with testosterone replacement therapy in men with late-onset hypogonadism: 5-year prospective, observational and longitudinal registry study.
Observational study in World journal of urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in Older Men.The Journal of clinical endocrinology and metabolism · 2016Trial
- Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study).Asian journal of andrologyTrial
- Correlation Analysis between Hypogonadal Symptoms and Changes in Body Composition and Physical Fitness after Testosterone Treatment in Men with Testosterone Deficiency.The world journal of men's health · 2024Article
- Correlation between Higher Aging Males' Symptoms Scores and a Higher Risk of Lower Urinary Tract Symptoms.Journal of clinical medicine · 2023Article
- Voiding function improves under long-term testosterone treatment (TTh) in hypogonadal men, independent of prostate size.International urology and nephrology · 2023Article
- Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis.Frontiers in aging · 2023Article
- Testosterone Replacement Therapy in the Aged Male: Monitoring Patients' Quality of Life Utilizing Scoring Systems.International journal of general medicine · 2022Review
- Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms.International neurourology journal · 2021Article
- Factors Associated with Bothersome Lower Urinary Tract Symptoms in Middle-Aged Men Receiving Health Checkup.Scientific reports · 2019Article
- Improved Lower Urinary Tract Symptoms Associated With Testosterone Replacement Therapy in Japanese Men With Late-Onset Hypogonadism.American journal of men's health · 2018Article
- Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome.The world journal of men's health · 2018Review
- Testosterone Modifies Alterations to Detrusor Muscle after Partial Bladder Outlet Obstruction in Juvenile Mice.Frontiers in pediatrics · 2017Article
- Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism.Arab journal of urology · 2016Article
- Testosterone deficiency in the aging male.Therapeutic advances in urology · 2016Review
- Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats.The world journal of men's health · 2015Article
- Testosterone Replacement Therapy on the Natural History of Prostate Disease.Current urology reports · 2015Review
- Elderly men over 65 years of age with late-onset hypogonadism benefit as much from testosterone treatment as do younger men.Korean journal of urology · 2015Observational
- Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men.The aging male : the official journal of the International Society for the Study of the Aging Male · 2015Article
- Adverse effects of testosterone replacement therapy: an update on the evidence and controversy.Therapeutic advances in drug safety · 2014Review
- Transdermal testosterone replacement therapy in men.Drug design, development and therapy · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMany men with "late-onset hypogonadism" (LOH) experience lower urinary tract symptoms (LUTS) that can be distressing and may decrease quality of life. LUTS often appear in men when testosterone levels begin to decline, which could be a significant association. We investigated whether testosterone replacement could alleviate LUTS in men with LOH.
methodsTwo hundred and sixty-one hypogonadal patients (mean age 59.5 years) presenting with erectile dysfunction, having also been evaluated for LUTS, received a single testosterone undecanoate injection at day 1, at week 6 and quarterly thereafter. Parameters, including International Prostate Symptom Score (IPSS), post-voiding residual urine volume, transrectal ultrasound, prostate volume and prostate-specific antigen were measured at each treatment visit. Two hundred and fifty-nine patients were included in the full analysis set. These were subsequently divided into weight losers (L ≥ 5 % weight loss at last visit from baseline) and non-losers (NL). t test analyses were used to compare the IPSS means of these subgroups. The potentially confounding effect on IPSS of using the phosphodiesterase-5 inhibitor (PDE5i) vardenafil was also accounted for.
resultsMean IPSS showed a significant decrease with time following initiation of testosterone treatment (p < 0.05). No significant differences were observed in either IPSS between L and NL groups or in mean IPSS between vardenafil users and non-users.
conclusionTestosterone replacement is associated with improvements in LUTS which are not confounded by weight loss or PDE5i. The mechanisms of this association require further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.