ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2013
Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Continuous Delivery of Hyperpolarized Xenon-129 Gas Using a "Stopped-Flow" Clinical-Scale Cryogen-Free Hyperpolarizer.Analytical chemistry · 2025Article
- Multi-nuclear magnetic resonance spectroscopy: state of the art and future directions.Insights into imaging · 2022Review
- Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer.Molecules (Basel, Switzerland) · 2022Article
- Enabling Clinical Technologies for HyperpolarizedAngewandte Chemie (International ed. in English) · 2021Review
- Fast dynamic ventilation MRI of hyperpolarizedMagnetic resonance in medicine · 2018Article
- Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation.Scientific reports · 2017Article
- NMR Hyperpolarization Techniques of Gases.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Review
- Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.Magnetic resonance in medicine · 2016Article
- Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.Journal of the Royal Society, Interface · 2015Article
- Propane-The journal of physical chemistry. C, Nanomaterials and interfaces · 2014Article
- Temperature-ramped (129)Xe spin-exchange optical pumping.Analytical chemistry · 2014Article
- XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.Magnetic resonance imaging · 2014Article
- Multidimensional mapping of spin-exchange optical pumping in clinical-scale batch-mode 129Xe hyperpolarizers.The journal of physical chemistry. B · 2014Article
- A 3D-printed high power nuclear spin polarizer.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
As an alternative to cryogenic gas handling, hyperpolarized (hp) gas mixtures were extracted directly from the spin exchange optical pumping (SEOP) process through expansion followed by compression to ambient pressure for biomedical MRI applications. The omission of cryogenic gas separation generally requires the usage of high xenon or krypton concentrations at low SEOP gas pressures to generate hp (129)Xe or hp (83)Kr with sufficient MR signal intensity for imaging applications. Two different extraction schemes for the hp gasses were explored with focus on the preservation of the nuclear spin polarization. It was found that an extraction scheme based on an inflatable, pressure controlled balloon is sufficient for hp (129)Xe handling, while (83)Kr can efficiently be extracted through a single cycle piston pump. The extraction methods were tested for ex vivo MRI applications with excised rat lungs. Precise mixing of the hp gases with oxygen, which may be of interest for potential in vivo applications, was accomplished during the extraction process using a piston pump. The (83)Kr bulk gas phase T1 relaxation in the mixtures containing more than approximately 1% O2 was found to be slower than that of (129)Xe in corresponding mixtures. The experimental setup also facilitated (129)Xe T1 relaxation measurements as a function of O2 concentration within excised lungs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.