ArticleBehavioural processes2014
Dissociations between interval timing and intertemporal choice following administration of fluoxetine, cocaine, or methamphetamine.
Article in Behavioural processes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of the Serotonergic System in Time Perception: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Circadian cilia transcriptome in mouse brain across physiological and pathological states.Molecular brain · 2024Article
- mPFC catecholamines modulate attentional capture by appetitive distracters and attention to time in a peak-interval procedure in rats.Behavioral neuroscience · 2022Article
- Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Article
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- How Psychoactive Drugs and the Circadian Clock Are Enlightening One Another.Advances in experimental medicine and biology · 2021Article
- Article
- Nucleus accumbens core lesions induce sub-optimal choice and reduce sensitivity to magnitude and delay in impulsive choice tasks.Behavioural brain research · 2018Article
- The hunt for the perfect discounting function and a reckoning of time perception.Current opinion in neurobiology · 2016Review
- Effect of 5-HT2A and 5-HT2C receptors on temporal discrimination by mice.Neuropharmacology · 2016Article
- Time discounting and time preference in animals: A critical review.Psychonomic bulletin & review · 2016Review
- Cognitive Aging and Time Perception: Roles of Bayesian Optimization and Degeneracy.Frontiers in aging neuroscience · 2016Review
- Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task.PloS one · 2015Article
- Individual differences in impulsive and risky choice: effects of environmental rearing conditions.Behavioural brain research · 2014Article
- Rationalizing Decision-Making: Understanding the Cost and Perception of Time.Timing & time perception reviews · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The goal of our study was to characterize the relationship between intertemporal choice and interval timing, including determining how drugs that modulate brain serotonin and dopamine levels influence these two processes. In Experiment 1, rats were tested on a standard 40-s peak-interval procedure following administration of fluoxetine (3, 5, or 8 mg/kg) or vehicle to assess basic effects on interval timing. In Experiment 2, rats were tested in a novel behavioral paradigm intended to simultaneously examine interval timing and impulsivity. Rats performed a variant of the bi-peak procedure using 10-s and 40-s target durations with an additional "defection" lever that provided the possibility of a small, immediate reward. Timing functions remained relatively intact, and 'patience' across subjects correlated with peak times, indicating a negative relationship between 'patience' and clock speed. We next examined the effects of fluoxetine (5 mg/kg), cocaine (15 mg/kg), or methamphetamine (1 mg/kg) on task performance. Fluoxetine reduced impulsivity as measured by defection time without corresponding changes in clock speed. In contrast, cocaine and methamphetamine both increased impulsivity and clock speed. Thus, variations in timing may mediate intertemporal choice via dopaminergic inputs. However, a separate, serotonergic system can affect intertemporal choice without affecting interval timing directly. This article is part of a Special Issue entitled: Associative and Temporal Learning.
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