ArticleJournal of the International Neuropsychological Society : JINS2014
Multivariate pattern analysis of FMRI in breast cancer survivors and healthy women.
Article in Journal of the International Neuropsychological Society : JINS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Mapping cognitive deficits in cancer patients after chemotherapy: An Activation Likelihood Estimation meta-analysis of task-related fMRI studies.Brain imaging and behavior · 2022Pooled it
- Cognitive impairment after chemotherapy related to atypical network architecture for executive control.Oncology · 2015Trial
- Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia.Pediatric blood & cancer · 2014Trial
- Neural mechanisms of CALM intervention to improve CRCI in breast cancer survivors: an fMRI-based study.American journal of cancer research · 2025Article
- Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment.Frontiers in medicine · 2023Review
- Classification of Chemotherapy-Related Subjective Cognitive Complaints in Breast Cancer Using Brain Functional Connectivity and Activity: A Machine Learning Analysis.Journal of clinical medicine · 2022Article
- Effect of chemotherapy on default mode network connectivity in older women with breast cancer.Brain imaging and behavior · 2022Article
- Functional connectome biotypes of chemotherapy-related cognitive impairment.Journal of cancer survivorship : research and practice · 2020Article
- Identifying cytokine predictors of cognitive functioning in breast cancer survivors up to 10 years post chemotherapy using machine learning.Journal of neuroimmunology · 2018Article
- Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy.NeuroImage. Clinical · 2018Article
- The attention network changes in breast cancer patients receiving neoadjuvant chemotherapy: Evidence from an arterial spin labeling perfusion study.Scientific reports · 2017Article
- Mechanisms of Neurotoxic Symptoms as a Result of Breast Cancer and Its Treatment: Considerations on the Contribution of Stress, Inflammation, and Cellular Bioenergetics.Current breast cancer reports · 2017Review
- Anomalous gray matter patterns in specific reading comprehension deficit are independent of dyslexia.Annals of dyslexia · 2016Article
- A clinically relevant dose of cyclophosphamide chemotherapy impairs memory performance on the delayed spatial alternation task that is sustained over time as mice age.Neurotoxicology · 2016Article
- Chemotherapy-related cognitive impairment in older patients with cancer.Journal of geriatric oncology · 2016Review
- Radiation-induced functional connectivity alterations in nasopharyngeal carcinoma patients with radiotherapy.Medicine · 2016Article
- Relationship between fruit and vegetable intake and interference control in breast cancer survivors.European journal of nutrition · 2016Article
- Atypical Structural Connectome Organization and Cognitive Impairment in Young Survivors of Acute Lymphoblastic Leukemia.Brain connectivity · 2016Article
- Neurotoxic Effects of Anthracycline- vs Nonanthracycline-Based Chemotherapy on Cognition in Breast Cancer Survivors.JAMA oncology · 2016Observational
- Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer.Neurobiology of aging · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Advances in breast cancer (BC) treatments have resulted in significantly improved survival rates. However, BC chemotherapy is often associated with several side effects including cognitive dysfunction. We applied multivariate pattern analysis (MVPA) to functional magnetic resonance imaging (fMRI) to find a brain connectivity pattern that accurately and automatically distinguishes chemotherapy-treated (C+) from non-chemotherapy treated (C-) BC females and healthy female controls (HC). Twenty-seven C+, 29 C-, and 30 HC underwent fMRI during an executive-prefrontal task (Go/Nogo). The pattern of functional connectivity associated with this task discriminated with significant accuracy between C+ and HC groups (72%, p = .006) and between C+ and C- groups (71%, p = .012). However, the accuracy of discrimination between C- and HC was not significant (51%, p = .46). Compared with HC, behavioral performance of the C+ and C- groups during the task was intact. However, the C+ group demonstrated altered functional connectivity in the right frontoparietal and left supplementary motor area networks compared to HC, and in the right middle frontal and left superior frontal gyri networks, compared to C-. Our results provide further evidence that executive function performance may be preserved in some chemotherapy-treated BC survivors through recruitment of additional neural connections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.