ArticleDevelopmental biology2013
Cellular mechanics of germ band retraction in Drosophila.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- DynamicAtlas: a morphodynamic atlas for Drosophila development.Nature methods · 2026Article
- A role for Myosin in triggering and executing amnioserosa cell delaminations during dorsal closure.Scientific reports · 2025Article
- A minimal vertex model explains how the amnioserosa avoids fluidization duringProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Confinement promotes nematic alignment of spindle-shaped cells during Drosophila embryogenesis.Development (Cambridge, England) · 2024Article
- Article
- How two extraembryonic epithelia became one: serosa and amnion features and functions ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Setting up for gastrulation: D. melanogaster.Current topics in developmental biology · 2020Review
- Elongated Cells Drive Morphogenesis in a Surface-Wrapped Finite-Element Model of Germband Retraction.Biophysical journal · 2019Article
- Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila.PLoS genetics · 2019Article
- Identifying Genetic Players in Cell Sheet Morphogenesis Using aG3 (Bethesda, Md.) · 2018Article
- Post-Turing tissue pattern formation: Advent of mechanochemistry.PLoS computational biology · 2018Article
- Anisotropic Müller glial scaffolding supports a multiplex lattice mosaic of photoreceptors in zebrafish retina.Neural development · 2017Article
- Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.Annual review of cell and developmental biology · 2017Review
- Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds.Biophysical journal · 2017Article
- Pathway to a phenocopy: Heat stress effects in early embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Article
- Modeling cell elongation during germ band retraction: cell autonomy versus applied anisotropic stress.New journal of physics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Germ band retraction involves a dramatic rearrangement of the tissues on the surface of the Drosophila embryo. As germ band retraction commences, one tissue, the germ band, wraps around another, the amnioserosa. Through retraction the two tissues move cohesively as the highly elongated cells of the amnioserosa contract and the germ band moves so it is only on one side of the embryo. To understand the mechanical drivers of this process, we designed a series of laser ablations that suggest a mechanical role for the amnioserosa. First, we find that during mid retraction, segments in the curve of the germ band are under anisotropic tension. The largest tensions are in the direction in which the amnioserosa contracts. Second, ablating one lateral flank of the amnioserosa reduces the observed force anisotropy and leads to retraction failures. The other intact flank of amnioserosa is insufficient to drive retraction, but can support some germ band cell elongation and is thus not a full phenocopy of ush mutants. Another ablation-induced failure in retraction can phenocopy mys mutants, and does so by targeting amnioserosa cells in the same region where the mutant fails to adhere to the germ band. We conclude that the amnioserosa must play a key, but assistive, mechanical role that aids uncurling of the germ band.
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