ArticleJournal of virological methods2014
Human bocavirus 1 infects commercially available primary human airway epithelium cultures productively.
Article in Journal of virological methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Molecular signaling in coinfection: howFrontiers in immunology · 2026Review
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- The prevalence and genetic characteristics of human bocavirus in patients with acute respiratory infection in China during 2012-2021.Biosafety and health · 2025Article
- MA104 cell line is permissive for human bocavirus 1 infection.Journal of virology · 2025Article
- Proteomic, Metabolomic, and Lipidomic Analyses of Lung Tissue Exposed to Mustard Gas.Metabolites · 2022Article
- The small nonstructural protein NP1 of human bocavirus 1 directly interacts with Ku70 and RPA70 and facilitates viral DNA replication.PLoS pathogens · 2022Article
- The Large Nonstructural Protein (NS1) of Human Bocavirus 1 Directly Interacts with Ku70, Which Plays an Important Role in Virus Replication in Human Airway Epithelia.Journal of virology · 2022Article
- Hairpin Transfer-Independent Parvovirus DNA Replication Produces Infectious Virus.Journal of virology · 2021Article
- Airway tight junctions as targets of viral infections.Tissue barriers · 2021Article
- Inhibition of Coronavirus EntrymBio · 2020Article
- Human Bocavirus 1 Infection of Well-Differentiated Human Airway Epithelium.Current protocols in microbiology · 2020Article
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- Cellular Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Mediates Nuclear Import of Human Bocavirus 1 NP1 Protein and Modulates Viral Capsid Protein Expression.Journal of virology · 2020Article
- Human bocavirus infection in Belgian children with respiratory tract disease.Archives of virology · 2019Article
- Anti-H7N9 avian influenza A virus activity of interferon in pseudostratified human airway epithelium cell cultures.Virology journal · 2019Article
- A Comprehensive RNA-seq Analysis of Human Bocavirus 1 Transcripts in Infected Human Airway Epithelium.Viruses · 2019Article
- The Human Bocavirus 1 NP1 Protein Is a Multifunctional Regulator of Viral RNA Processing.Journal of virology · 2018Article
- Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region.BMC infectious diseases · 2018Article
- Possible risks posed by single-stranded DNA viruses of pigs associated with xenotransplantation.Xenotransplantation · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Human bocavirus 1 (HBoV1), a human parvovirus, belongs to the genus Bocavirus of the Parvoviridae family. It causes wheezing in young children with acute respiratory tract infections. HBoV1 has been shown to infect polarized human airway epithelium (HAE) made in house, and induces airway epithelial damage. In this study, two commercially available HAE cultures, EpiAirway and MucilAir HAE, were examined for HBoV1 infection. Both HAE cultures support fully productive HBoV1 infection. Infected EpiAirway and MucilAir HAE cultures showed loss of cilia, disruption of the tight junction barrier, and a significant decrease in transepithelial electrical resistance. Notably, HBoV1 persistent infection was demonstrated by maintaining HBoV1-infected EpiAirway HAE for as long as 50 days. After 2 days post-infection, progeny virus was produced consistently daily at a level of over 2×10(8) viral genome copies per culture (0.6 cm(2)). This study is the first to use commercial sources of HAE cultures for HBoV1 infection. The availability of these cultures will enable a wide range of laboratories to study HBoV1 infection.
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