ArticleClinical and experimental immunology2014
CD4(+) CD25(high) forkhead box protein 3(+) regulatory T lymphocytes suppress interferon-γ and CD107 expression in CD4(+) and CD8(+) T cells from tuberculous pleural effusions.
Article in Clinical and experimental immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
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- The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy especially in tuberculous pleurisy.Respiratory research · 2024Review
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- A Phenotypic Characterization of Two Isolates of a Multidrug-Resistant Outbreak Strain ofBioMed research international · 2020Article
- Metabolic Regulation of Immune Responses toFrontiers in immunology · 2020Review
- Predominance of Th1 Immune Response in Pleural Effusion of Patients with Tuberculosis among Other Exudative Etiologies.Journal of clinical microbiology · 2019Article
- Immunology ofMicrobiology spectrum · 2019Review
- Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma.Nature communications · 2019Article
- Frequency of Circulating CD4Frontiers in immunology · 2018Article
- Ex-vivo characterization of regulatory T cells in pulmonary tuberculosis patients, latently infected persons, and healthy endemic controls.Tuberculosis (Edinburgh, Scotland) · 2016Article
- Reduced potency of cytotoxic T lymphocytes from patients with high-risk myelodysplastic syndromes.Cancer immunology, immunotherapy : CII · 2016Article
- Elevated neutrophil-to-lymphocyte ratio is an independent poor prognostic factor in patients with intrahepatic cholangiocarcinoma.Oncotarget · 2016Article
- Decreased IL-17 during treatment of sputum smear-positive pulmonary tuberculosis due to increased regulatory T cells and IL-10.Journal of translational medicine · 2016Article
- Tuberculous pleurisy drives marked effector responses of γδ, CD4+, and CD8+ T cell subpopulations in humans.Journal of leukocyte biology · 2015Article
- T regulatory cells: Achilles' heel of Mycobacterium tuberculosis infection?Immunologic research · 2015Review
- High IL-35 pleural expression in patients with tuberculous pleural effusion.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- LAG3 expression in active Mycobacterium tuberculosis infections.The American journal of pathology · 2015Article
- Regulatory T-Cells at the Interface between Human Host and Pathogens in Infectious Diseases and Vaccination.Frontiers in immunology · 2015Review
- Cytotoxic response of human regulatory T cells upon T-cell receptor-mediated activation: a matter of purity.Blood cancer journal · 2014Article
- Regulatory T Cell Activity and Signs of T Cell Unresponsiveness in Bovine Paratuberculosis.Frontiers in veterinary science · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculous pleural effusion is characterized by a T helper type 1 (Th1) profile, but an excessive Th1 response may also cause tissue damage that might be controlled by regulatory mechanisms. In the current study we investigated the role of regulatory T cells (Treg ) in the modulation of Th1 responses in patients with tuberculous (TB) pleurisy. Using flow cytometry we evaluated the proportion of Treg (CD4(+) CD25(high) forkhead box protein 3(+) ), interferon (IFN)-γ and interleukin (IL)-10 expression and CD107 degranulation in peripheral blood (PB) and pleural fluid (PF) from patients with TB pleurisy. We demonstrated that the proportion of CD4(+) CD25(+) , CD4(+) CD25(high) FoxP3(+) and CD8(+) CD25(+) cells were increased in PF compared to PB samples. Mycobacterium tuberculosis stimulation increased the proportion of CD4(+) CD25(low/neg) IL-10(+) in PB and CD4(+) CD25(low/neg) IFN-γ(+) in PF; meanwhile, CD25(high) mainly expressed IL-10 in both compartments. A high proportion of CD4(+) CD107(+) and CD8(+) CD107(+) cells was observed in PF. Treg depletion enhanced the in-vitro M. tuberculosis-induced IFN-γ and CD4(+) and CD8(+) degranulation responses and decreased CD4(+) IL-10(+) cells in PF. Our results demonstrated that in TB pleurisy Treg cells effectively inhibit not only IFN-γ expression but also the ability of CD4(+) and CD8(+) cells to degranulate in response to M. tuberculosis.
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