ArticleJournal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie2014
Assessing the impact of genomic selection against hip dysplasia in the Labrador Retriever dog.
Article in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Genomic information increases prediction accuracy of behavior traits of Labrador Retrievers used as guide dogs.Genetics, selection, evolution : GSE · 2026Article
- Article
- The association of genetic polymorphisms of bone formation genes with canine hip dysplasia.Iranian journal of veterinary research · 2020Article
- Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci.BMC genomics · 2019Article
- Accuracy of genotype imputation in Labrador Retrievers.Animal genetics · 2018Article
- Use and optimization of different sources of information for genomic prediction.Genetics, selection, evolution : GSE · 2017Article
- Genomic data illuminates demography, genetic structure and selection of a popular dog breed.BMC genomics · 2017Article
- Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds.PloS one · 2017Article
- Emerging insights into the genetic basis of canine hip dysplasia.Veterinary medicine (Auckland, N.Z.) · 2015Review
- The challenges of pedigree dog health: approaches to combating inherited disease.Canine genetics and epidemiology · 2015Article
- A genetic predictive model for canine hip dysplasia: integration of Genome Wide Association Study (GWAS) and candidate gene approaches.PloS one · 2015Article
- Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Many purebred dogs exhibit a higher prevalence of inherited diseases compared with non-purebred dogs. One of the most popular breeds in the UK is the Labrador Retriever, which has a high prevalence of hip dysplasia resulting in high costs for surgical operations and impaired animal welfare. Considering the many complications of highly managed populations, mainly due to breeder's conventions and the resulting population structure, is of great importance for the proper development of a strategy against the disease. In this study, we have compared the utilities and performances of both genomic and phenotypic selection against hip dysplasia in a simulated population with the characteristics of the British Veterinary Association and Kennel Club (BV /KC) hip dysplasia scheme. The results confirm the potential benefits of genomic selection by showing a moderate increase of 1.15-fold (assuming a realistic accuracy of r(2) = 0.5) in response to selection due to the higher accuracy (between 0.96- and 1.32-fold, considering 0.35 ≤ r(2) ≤ 0.7) and more than a threefold increase when all the offspring in each litter are tested (between 3.25- and 4.55-fold, again considering 0.35 ≤ r(2) ≤ 0.7).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.