Evidence map›Paper›PMID 24134194›Full record

Trial reportRejuvenation research2014

Nutraceutical intervention improves older adults' cognitive functioning.

Brent J Small, Kerri S Rawson, Christina Martin, Sarah L Eisel, Cyndy D Sanberg, Cathy L McEvoy, Paul R Sanberg, R Douglas Shytle, Jun Tan, Paula C Bickford

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Rejuvenation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brent J Small1 School of Aging Studies, University of South Florida , Tampa, Florida.
Kerri S Rawson
Christina Martin
Sarah L Eisel
Cyndy D Sanberg
Cathy L McEvoy
Paul R Sanberg
R Douglas Shytle
Jun Tan
Paula C Bickford

Funding

Training in the Genetics and Molecular Biology of Mental DisordersT32MH014677 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1985 to 2020
$3.6M
Octyl gallate (OG) and Promotion of non-amyloidogenic processing of APPI01BX001143 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI TAN, JUN · 2013 to 2016
–
BLRD VA I01 BX001143NIMH NIH HHS T32 MH014677
6 · The paper itself

Abstract

Interventions to improve the cognitive health of older adults are of critical importance. In the current study, we conducted a double-blind, placebo-controlled clinical trial using a pill-based nutraceutical (NT-020) that contained a proprietary formulation of blueberry, carnosine, green tea, vitamin D3, and Biovin to evaluate the impact on changes in multiple domains of cognitive functioning. One hundred and five cognitively intact adults aged 65-85 years of age (M=73.6 years) were randomized to receive NT-020 (n=52) or a placebo (n=53). Participants were tested with a battery of cognitive performance tests that were classified into six broad domains--episodic memory, processing speed, verbal ability, working memory, executive functioning, and complex speed at baseline and 2 months later. The results indicated that persons taking NT-020 improved significantly on two measures of processing speed across the 2-month test period in contrast to persons on the placebo whose performance did not change. None of the other cognitive ability measures were related to intervention group. The results also indicated that the NT-020 was well tolerated by older adults, and the presence of adverse events or symptoms did not differ between the NT-020 and placebo groups. Overall, the results of the current study were promising and suggest the potential for interventions like these to improve the cognitive health of older adults.

Indexed as

Dietary SupplementsAdultAgedAged, 80 and overCognitionFemaleFollow-Up StudiesHumansMalePatient CompliancePlacebosPlacebos

Identifiers

PMID24134194
PMCPMC4047846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.