ArticleChemical research in toxicology2013
Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation.
Article in Chemical research in toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 88 citations in OpenAlex.
- Microbial metabolite Urolithin A protects against inorganic arsenic-induced gut barrier dysfunction in humanizedGut microbes · 2026Article
- Arsenic Methyltransferase Function in Inorganic Arsenic Biotransformation: Implications for Health Risks and Disease Development.Biological trace element research · 2026Review
- Technical and biological factors driving inter-individual body burden of arsenic species in murine models of human arsenic exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Advanced Membrane Simulations in Probiotics and Gut Microbiome Interaction Research: The Current Trends and Insights.Current pharmaceutical design · 2025Review
- Intestinal microbiota dysbiosis contributes to the liver damage in subchronic arsenic-exposed mice.Acta biochimica et biophysica Sinica · 2024Article
- Dynamic Effect of β-Lactam Antibiotic Inactivation Due to the Inter- and Intraspecies Interaction of Drug-Resistant Microbes.ACS biomaterials science & engineering · 2024Article
- Prenatal exposures to endocrine disrupting chemicals: The role of multi-omics in understanding toxicity.Molecular and cellular endocrinology · 2023Review
- Contribution of gut bacteria to arsenic metabolism in the first year of life in a prospective birth cohort.Environmental research · 2022Article
- Impact of antibiotics on the human microbiome and consequences for host health.MicrobiologyOpen · 2022Review
- Interactions between arsenic exposure, high-fat diet and NRF2 shape the complex responses in the murine gut microbiome and hepatic metabolism.Frontiers in microbiomes · 2022Article
- The Need to Unravel Arsenolipid Transformations in Humans.DNA and cell biology · 2022Article
- Nutrition, one-carbon metabolism and arsenic methylation.Toxicology · 2021Review
- The gut microbiome and arsenic-induced disease-iAs metabolism in mice.Current environmental health reports · 2021Review
- Ameliorative effect of graphene nanosheets against arsenic-induced toxicity in mice by oral exposure.Environmental science and pollution research international · 2021Article
- Introducing the ArsR-Regulated Arsenic Stimulon.Frontiers in microbiology · 2021Article
- Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases.Toxics · 2020Review
- Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- The gut microbiome: an orchestrator of xenobiotic metabolism.Acta pharmaceutica Sinica. B · 2020Review
- The Human Gut Microbiome's Influence on Arsenic Toxicity.Current pharmacology reports · 2019Article
- Pharmacokinetic Properties of Arsenic Species after Intravenous and Intragastrical Administration of Arsenic Trioxide Solution in Cynomolgus Macaques Using HPLC-ICP-MS.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Exposure to arsenic affects large human populations worldwide and has been associated with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, and cardiovascular disorders. In addition, there are large individual differences in susceptibility to arsenic-induced diseases, which are frequently associated with different patterns of arsenic metabolism. Several underlying mechanisms, such as genetic polymorphisms and epigenetics, have been proposed, as these factors closely impact the individuals' capacity to metabolize arsenic. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that perturbations of the gut microbial communities affect the spectrum of metabolized arsenic species and subsequent toxicological effects. In this study, we used an animal model with an altered gut microbiome induced by bacterial infection, 16S rRNA gene sequencing, and inductively coupled plasma mass spectrometry-based arsenic speciation to examine the effect of gut microbiome perturbations on the biotransformation of arsenic. Metagenomics sequencing revealed that bacterial infection significantly perturbed the gut microbiome composition in C57BL/6 mice, which in turn resulted in altered spectra of arsenic metabolites in urine, with inorganic arsenic species and methylated and thiolated arsenic being perturbed. These data clearly illustrated that gut microbiome phenotypes significantly affected arsenic metabolic reactions, including reduction, methylation, and thiolation. These findings improve our understanding of how infectious diseases and environmental exposure interact and may also provide novel insight regarding the gut microbiome composition as a new risk factor of individual susceptibility to environmental chemicals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.