ArticleWorld journal of surgical oncology2013
Family history of hepatocellulcar carcinoma is not associated with its patients' prognosis after hepatectomy.
Article in World journal of surgical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The clinical behavior and survival of patients with hepatocellular carcinoma and a family history of the disease.Cancer medicine · 2019Article
- Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma.Hepatobiliary surgery and nutrition · 2019Article
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6 authors.
Funding
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Abstract
backgroundFamily history of liver cancer is a major risk factor for hepatocellular carcinoma (HCC). In this study, we investigated the prognosis of patients with HCC with or without family history.
methodsData for 1,313 patients who underwent hepatectomy as initial treatment for HCC between 2000 and 2008 at a tertiary cancer center hospital were retrieved from a prospective database. A positive family history was defined as a self-reported history of HCC in first-degree relatives. Clinicopathologic characteristics were compared by family history. Kaplan-Meier method and Cox proportional hazards regressions were applied for overall survival (OS) and disease-free survival (DFS).
resultsOf 1,313 patients, 169 patients (12.9%) had first-degree relatives with a history of HCC. There were no significant differences between patients with or without family history in basic clinicopathologic characteristics. In either whole group or each stage according to the TNM staging system, first-degree family history was not associated with survival in all patients, hepatitis B virus-positive patients, as well as male patients. Multivariate analysis revealed that first-degree family history was not a prognostic factor, either for OS or DFS.
conclusionA first-degree family history of HCC is not associated with its patients' prognosis after hepatectomy.
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