ArticleInternational journal of clinical and experimental pathology2013
Methotrexate-related Epstein-Barr virus-associated lymphoproliferative disorder occurring in the gingiva of a patient with rheumatoid arthritis.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Strawberry Gingivitis: Rare Early Manifestation of Relapsing Granulomatosis with PolyangiitisBalkan medical journal · 2025Article
- Magnetic resonance imaging of methotrexate-related lymphoproliferative disorder with a chief complaint of oral symptoms.Oral radiology · 2023Article
- Unusual manifestation of methotrexate-associated lymphoproliferative disorder as a palatal mass.BMJ case reports · 2022Article
- Clinicopathological evaluation of methotrexate-associated lymphoproliferative disorders with special focus on Epstein-Barr virus-positive mucocutaneous lesions.Journal of clinical and experimental hematopathology : JCEH · 2020Article
- Clinical management for other iatrogenic immunodeficiency-associated lymphoproliferative disorders.Journal of clinical and experimental hematopathology : JCEH · 2019Review
- Oral Methotrexate-related Lymphoproliferative Disease Presenting with Severe Osteonecrosis of the Jaw: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2018Review
- The impact of inflammatory bowel disease on oral health.British dental journal · 2017Review
- Atypical methotrexate ulcerative stomatitis with features of lymphoproliferative like disorder: Report of a rare ciprofloxacin-induced case and review of the literature.Journal of clinical and experimental dentistry · 2016Article
- Oral pathology in inflammatory bowel disease.World journal of gastroenterology · 2016Review
- Ectopic respiratory mucosa in the rectum: the second documented case with discussion of its histogenesis.International journal of clinical and experimental pathology · 2014Review
- Elastofibromatous change of the intestine: report of four lesions from three patients with review of the literature.International journal of clinical and experimental pathology · 2014Review
- Cutaneous mastocytosis with abundant eosinophilic infiltration: a case report with review of the literature.International journal of clinical and experimental pathology · 2014Review
- Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp.International journal of clinical and experimental pathology · 2014Article
- Small cell carcinoma of the endometrium: a case report with emphasis on the cytological features.International journal of clinical and experimental pathology · 2014Article
- Cytological features of lung adenocarcinoma with micropapillary pattern in the pleural or pericardial effusion: analysis of 5 cases.International journal of clinical and experimental pathology · 2014Article
- Apocrine hidrocystoma with mucinous metaplasia.International journal of clinical and experimental pathology · 2014Article
- Concomitant occurrence of IgG4-related pleuritis and periaortitis: a case report with review of the literature.International journal of clinical and experimental pathology · 2014Review
- Skin erythema with leukocytoclastic vasculitis and elastophagocytosis as the presenting features of an underlying myelodysplastic syndrome.International journal of clinical and experimental pathology · 2014Article
- Primary cutaneous B-cell lymphoma with abundant reactive gamma/delta T-cells within the skin lesion and peripheral blood.International journal of clinical and experimental pathology · 2014Article
- IgD plasmablastic myeloma: a case report with emphasis on the cytological features.International journal of clinical and experimental pathology · 2014Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well recognized that patients with immunodeficiency have a high risk of development of lymphoproliferative disorders (LPDs), and Epstein-Barr virus (EBV) is associated with the occurrence of LPDs. Methotrexate (MTX) is one of the common cause of iatrogenic-associated LPD, and approximately 40-50% of MTX-related LPD cases occur in extranodal sites. However, the occurrence of MTX-related LPD in the gingiva is extremely rare. Herein, we report the fourth documented case of MTX-related EBV-associated LPD occurring in the gingiva of a patient with rheumatoid arthritis (RA). A 76-year-old Japanese female with a 10-year history of RA, who was treated with MTX and infliximab, presented with a tumorous lesion in the gingiva. Biopsy of the gingiva tumor revealed diffuse proliferation of large-sized lymphoid cells with cleaved nuclei containing conspicuous nucleoli. These lymphoid cells were CD20- and EBER-positive. Therefore, a diagnosis of MTX-related EBV-associated LPD showing features of diffuse large B-cell lymphoma (DLBCL) that occurred in the gingiva was made. Although the occurrence of LPD in the oral region, as seen in the present case, is rare, the prevalence of this disorder may be on the rise due to the increased number of patients undergoing immunosuppression therapy. Moreover, immunosenescence can also be a cause of EBV-associated LPD. Therefore, recognition of the occurrence of this disorder in the oral cavity and consideration of the clinical history can facilitate the correct diagnosis.
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24133604PMC3796248W65288262What OpenQuestion holds
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