ReviewFrontiers in immunology2013
The Influence of Mucus Microstructure and Rheology in Helicobacter pylori Infection.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 132 citations in OpenAlex.
- Nanomechanical Hallmarks ofInternational journal of molecular sciences · 2021Trial
- Probing the Luminal Compartment of 3D Organoids via Particle Tracking Microrheology.Bio-protocol · 2026Article
- Physical, chemical, and structural properties of human gastric organoid-derived mucus.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026Review
- Physical, chemical, and structural properties of human gastric organoid-derived mucus.bioRxiv : the preprint server for biology · 2025Article
- Innovative microfluidic model for investigating the intestinal mucus barrier: numerical and experimental perspectives.Drug delivery and translational research · 2025Article
- Macroheterogeneities Induced by Disulfide Bond Reduction in Native Mucus.ACS applied bio materials · 2025Article
- Nanoparticle Dynamics near Polyacrylamide Gel Interfaces.ACS polymers Au · 2025Article
- The influence ofComputational and structural biotechnology journal · 2024Review
- Screening Probiotics for Anti-Foods (Basel, Switzerland) · 2024Article
- Air-liquid intestinal cell culture allowsAPL bioengineering · 2024Article
- Microbes in porous environments: from active interactions to emergent feedback.Biophysical reviews · 2024Review
- Understanding the Influence of Rheology on Biofilm Adhesion and Implication for Food Safety.International journal of food science · 2024Review
- Unraveling the Intertwined Effect of pH onMicroorganisms · 2023Article
- Validation of a Novel Endoscopic Feature that PredictsThe Korean journal of helicobacter and upper gastrointestinal research · 2023Article
- Article
- The Role of Adhesion in Helicobacter pylori Persistent Colonization.Current microbiology · 2023Review
- Article
- Motility of Different GastricMicroorganisms · 2023Review
- Frustrated 'run and tumble' of swimmingInterface focus · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The bacterium Helicobacter pylori (H. pylori), has evolved to survive in the highly acidic environment of the stomach and colonize on the epithelial surface of the gastric mucosa. Its pathogenic effects are well known to cause gastritis, peptic ulcers, and gastric cancer. In order to infect the stomach and establish colonies on the mucus epithelial surface, the bacterium has to move across the gel-like gastric mucus lining of the stomach under acidic conditions. In this review we address the question of how the bacterium gets past the protective mucus barrier from a biophysical perspective. We begin by reviewing the molecular structure of gastric mucin and discuss the current state of understanding concerning mucin polymerization and low pH induced gelation. We then focus on the viscoelasticity of mucin in view of its relevance to the transport of particles and bacteria across mucus, the key first step in H. pylori infection. The second part of the review focuses on the motility of H. pylori in mucin solutions and gels, and how infection with H. pylori in turn impacts the viscoelastic properties of mucin. We present recent microscopic results tracking the motion of H. pylori in mucin solutions and gels. We then discuss how the biochemical strategy of urea hydrolysis required for survival in the acid is also relevant to the mechanism that enables flagella-driven swimming across the mucus gel layer. Other aspects of the influence of H. pylori infection such as, altering gastric mucin expression, its rate of production and its composition, and the influence of mucin on factors controlling H. pylori virulence and proliferation are briefly discussed with references to relevant literature.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.