ReviewFrontiers in endocrinology2013
De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar/AGC1.
Review in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids.Cell reports · 2025Article
- Aspartate in the Brain: A Review.Neurochemical research · 2025Review
- Asparagine Availability Is a Critical Limiting Factor for Infectious Spleen and Kidney Necrosis Virus Replication.Viruses · 2024Article
- Improvement in the prediction power of an astrocyte genome-scale metabolic model using multi-omic data.Frontiers in systems biology · 2024Article
- High-physiological and supra-physiological 1,2-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Aspartic Acid in Health and Disease.Nutrients · 2023Review
- Inborn disorders of the malate aspartate shuttle.Journal of inherited metabolic disease · 2021Review
- Antiepileptogenic Effect of Retinoic Acid.Current neuropharmacology · 2021Article
- Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis.Frontiers in psychiatry · 2021Review
- Review
- The retina and retinal pigment epithelium differ in nitrogen metabolism and are metabolically connected.The Journal of biological chemistry · 2020Article
- A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain.Journal of neurotrauma · 2018Article
- Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs.Molecular neurobiology · 2017Review
- Malate-aspartate shuttle inhibitor aminooxyacetic acid blocks lipopolysaccharides-induced activation of BV2 microglia.International journal of physiology, pathophysiology and pharmacology · 2017Article
- Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017Review
- Uncoupling Protein 2 (UCP2) Function in the Brain as Revealed by the Cerebral Metabolism of (1-Neurochemical research · 2017Article
- Malate-Aspartate Shuttle Inhibitor Aminooxyacetate Acid Induces Apoptosis and Impairs Energy Metabolism of Both Resting Microglia and LPS-Activated Microglia.Neurochemical research · 2015Article
- Why are astrocytes important?Neurochemical research · 2015Review
- Aralar plays a significant role in maintaining the survival and mitochondrial membrane potential of BV2 microglia.International journal of physiology, pathophysiology and pharmacology · 2015Article
- Malate-aspartate shuttle mediates the intracellular ATP levels, antioxidation capacity and survival of differentiated PC12 cells.International journal of physiology, pathophysiology and pharmacology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.