ArticleFrontiers in psychiatry2013
Frequency and neural correlates of pauses in patients with formal thought disorder.
Article in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuropsychological dimensions related to alterations of verbal self-monitoring neural networks in schizophrenic language: systematic review.Frontiers in psychiatry · 2024Pooled it
- Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis.Human brain mapping · 2017Pooled it
- Deeper insight into speech characteristics of patients at ultra-high risk using classification and explainability models.Frontiers in psychiatry · 2025Article
- Neural activation during natural speech and rests in patients with schizophrenia and schizophrenia spectrum disorders-an fMRI pilot trial.Frontiers in psychiatry · 2024Article
- Relative importance of speech and voice features in the classification of schizophrenia and depression.Translational psychiatry · 2023Article
- Negative symptoms and speech pauses in youths at clinical high risk for psychosis.NPJ schizophrenia · 2021Article
- Cognitive and Structural Correlates of Conversational Speech Timing in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease: Relevance for Early Detection Approaches.Frontiers in aging neuroscience · 2021Article
- Disturbing the rhythm of thought: Speech pausing patterns in schizophrenia, with and without formal thought disorder.PloS one · 2019Article
- Meta-Analysis of Functional Neuroimaging and Cognitive Control Studies in Schizophrenia: Preliminary Elucidation of a Core Dysfunctional Timing Network.Frontiers in psychology · 2016Article
- A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia.Frontiers in human neuroscience · 2015Review
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Authors and funding
6 authors.
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Abstract
backgroundPauses during speech may reflect the planning and monitoring of discourse, two processes putatively impaired in patients with schizophrenia, particularly those with formal thought disorder (FTD). We used functional MRI to examine the neural correlates of between-clause and of filled pauses, which are respectively associated with speech planning and speech monitoring.
methodsBOLD contrast was measured while six schizophrenia patients with FTD and six healthy subjects spoke about Rorshach inkblots. In an event-related design, we examined activity associated with pauses that occurred between clauses and with pauses that were filled.
resultsThere was no significant group difference in the frequency of between-clause pauses but patients with FTD made strikingly fewer filled pauses than controls. Between-clause pauses were associated with activation in the anterior part of the left superior temporal gyrus (STG) and the left insula in controls and the engagement of these regions was significantly attenuated in patients.
conclusionThe anterior part of the left STG and the left insula are normally involved in both the planning and monitoring of discourse. The attenuated engagement of these regions with between-clause pauses and the striking infrequency of filled pauses in the patients are consistent with cognitive models implicating defective speech planning and speech monitoring in schizophrenia, especially in relation to FTD.
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