ReviewFrontiers in psychiatry2013
Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD Research.
Review in Frontiers in psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychosocial factors and hippocampal subfields: The Medea-7T study.Human brain mapping · 2023Pooled it
- Effects of mindfulness training on posttraumatic stress symptoms from a community-based pilot clinical trial among survivors of intimate partner violence.Psychological trauma : theory, research, practice and policy · 2020Trial
- Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025Review
- Poverty Status at Birth Predicts Epigenetic Changes at Age 15.Journal of biomedical and life sciences · 2024Article
- A cross-sectional study of relationships between social risks and prevalence and severity of pediatric chronic conditions.BMC pediatrics · 2023Article
- Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder.Frontiers in psychiatry · 2022Review
- A longitudinal investigation of psychological distress in children during COVID-19: the role of socio-emotional vulnerability.European journal of psychotraumatology · 2022Article
- Links between mothers' ACEs, their psychopathology and parenting, and their children's behavior problems-A mediation model.Frontiers in psychiatry · 2022Article
- Association between Maternal Adverse Childhood Experiences and Risk of Post-traumatic Stress Disorder in the Offspring.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2021Article
- Addressing Intersecting Social and Mental Health Needs Among Transition-Age Homeless Youths: A Review of the Literature.Psychiatric services (Washington, D.C.) · 2021Review
- Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine.Frontiers in neuroscience · 2021Article
- Exercise-Based Interventions for Internet Addiction: Neurobiological and Neuropsychological Evidence.Frontiers in psychology · 2020Review
- A review of epigenetic contributions to post-traumatic stress disorder .Dialogues in clinical neuroscience · 2019Review
- Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation.Frontiers in psychiatry · 2019Review
- Epigenetic Programming Effects of Early Life Stress: A Dual-Activation Hypothesis.Current genomics · 2018Review
- Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
- The lingering impact of stress: brief acute glucocorticoid exposure has sustained, dose-dependent effects on reproduction.Proceedings. Biological sciences · 2018Article
- The stressed brain of humans and rodents.Acta physiologica (Oxford, England) · 2018Review
- Sleep problems over a year in sexually abused preschoolers.Paediatrics & child health · 2017Article
- Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom.Neurobiology of learning and memory · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood adversity can have life-long consequences for the response to stressful events later in life. Abuse or severe neglect are well-known risk factors for post-traumatic stress disorder (PTSD), at least in part via changes in neural systems mediating the endocrine response to stress. Determining the biological signatures of risk for stress-related mental disorders such as PTSD is important for identifying homogenous subgroups and improving treatment options. This review will focus on epigenetic regulation in early life by adversity and parental care - prime mediators of offspring neurodevelopment - in order to address several questions: (1) what have studies of humans and analogous animal models taught us about molecular mechanisms underlying changes in stress-sensitive physiological systems in response to early life trauma? (2) What are the considerations for studies relating early adversity and PTSD risk, going forward? I will summarize studies in animals and humans that address the epigenetic response to early adversity in the brain and in peripheral tissues. In so doing, I will describe work on the glucocorticoid receptor and other well-characterized genes within the stress response pathway and then turn to genomic studies to illustrate the use of increasingly powerful high-throughput approaches to the study of epigenomic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.