ReviewFrontiers in physiology2013
Mechanisms regulating nutrition-dependent developmental plasticity through organ-specific effects in insects.
Review in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 139 citations in OpenAlex.
- Probing metazoan polyphosphate biology usingeLife · 2026Article
- Transcriptomic basis underlying the evolution of female horn plasticity in scarab beetles.Frontiers in zoology · 2026Article
- Venom IMP-L2 from the EctoparasitoidInsects · 2025Article
- Long-term and short-term effects of a unicellular symbiont on its beetle host.Scientific reports · 2025Article
- Climate change-induced stress in the honey beeFrontiers in physiology · 2025Review
- RNAi-MediatedInsects · 2024Article
- The Molecular Substrates of Insect Eusociality.Annual review of genetics · 2024Review
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- Nesting cavity diameter has implications for management of the alfalfa leafcutting bee (Hymenoptera: Megachilidae).Journal of economic entomology · 2024Article
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- Article
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila.Nature communications · 2023Article
- Upregulation of Tribbles decreases body weight and increases sleep duration.Disease models & mechanisms · 2023Article
- A novel geneeLife · 2023Article
- 20-Hydroxyecdysone and Receptor Interplay in the Regulation of Hemolymph Glucose Level in Honeybee (Metabolites · 2023Article
- Involvement of Methoprene-tolerant and Krüppel homolog 1 in juvenile hormone-mediated vitellogenesis of female Liposcelis entomophila (End.) (Psocoptera: Liposcelididae).Archives of insect biochemistry and physiology · 2023Article
- RNA interference knockdown of insulin receptor inhibits ovarian development in Chilo suppressalis.Molecular biology reports · 2022Article
- Independent pathways control muscle tissue size and sarcomere remodeling.Developmental biology · 2022Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutrition, via the insulin/insulin-like growth factor (IIS)/Target of Rapamycin (TOR) signaling pathway, can provide a strong molding force for determining animal size and shape. For instance, nutrition induces a disproportionate increase in the size of male horns in dung and rhinoceros beetles, or mandibles in staghorn or horned flour beetles, relative to body size. In these species, well-fed male larvae produce adults with greatly enlarged horns or mandibles, whereas males that are starved or poorly fed as larvae bear much more modest appendages. Changes in IIS/TOR signaling plays a key role in appendage development by regulating growth in the horn and mandible primordia. In contrast, changes in the IIS/TOR pathway produce minimal effects on the size of other adult structures, such as the male genitalia in fruit flies and dung beetles. The horn, mandible and genitalia illustrate that although all tissues are exposed to the same hormonal environment within the larval body, the extent to which insulin can induce growth is organ specific. In addition, the IIS/TOR pathway affects body size and shape by controlling production of metamorphic hormones important for regulating developmental timing, like the steroid molting hormone ecdysone and sesquiterpenoid hormone juvenile hormone. In this review, we discuss recent results from Drosophila and other insects that highlight mechanisms allowing tissues to differ in their sensitivity to IIS/TOR and the potential consequences of these differences on body size and shape.
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