ArticleFrontiers in neural circuits2013
Three-dimensional mapping of microcircuit correlation structure.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Rapid adaptive optics enabling near noninvasive high-resolution brain imaging in awake behaving mice.Nature communications · 2025Article
- Transport in the brain studied withNeurophotonics · 2025Review
- Signal-to-signal neural networks for improved spike estimation from calcium imaging data.PLoS computational biology · 2021Article
- Integrated Neurophotonics: Toward Dense Volumetric Interrogation of Brain Circuit Activity-at Depth and in Real Time.Neuron · 2020Review
- Real-time 3D movement correction for two-photon imaging in behaving animals.Nature methods · 2020Article
- Illuminating dendritic function with computational models.Nature reviews. Neuroscience · 2020Review
- Inference of synaptic connectivity and external variability in neural microcircuits.Journal of computational neuroscience · 2020Article
- The temporal structure of the inner retina at a single glance.Scientific reports · 2020Article
- Wide. Fast. Deep: Recent Advances in Multiphoton Microscopy ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- Spike Estimation from Fluorescence Signals Using High-Resolution Property of Group Delay.IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society · 2019Article
- Community-based benchmarking improves spike rate inference from two-photon calcium imaging data.PLoS computational biology · 2018Article
- The structured 'low temperature' phase of the retinal population code.PLoS computational biology · 2017Article
- Article
- Error-Robust Modes of the Retinal Population Code.PLoS computational biology · 2016Article
- Consistent estimation of complete neuronal connectivity in large neuronal populations using sparse "shotgun" neuronal activity sampling.Journal of computational neuroscience · 2016Article
- Genetically Encoded Voltage Indicators: Opportunities and Challenges.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Technologies for imaging neural activity in large volumes.Nature neuroscience · 2016Review
- Improving data quality in neuronal population recordings.Nature neuroscience · 2016Review
- Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain.Nature biotechnology · 2016Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
Great progress has been made toward understanding the properties of single neurons, yet the principles underlying interactions between neurons remain poorly understood. Given that connectivity in the neocortex is locally dense through both horizontal and vertical connections, it is of particular importance to characterize the activity structure of local populations of neurons arranged in three dimensions. However, techniques for simultaneously measuring microcircuit activity are lacking. We developed an in vivo 3D high-speed, random-access two-photon microscope that is capable of simultaneous 3D motion tracking. This allows imaging from hundreds of neurons at several hundred Hz, while monitoring tissue movement. Given that motion will induce common artifacts across the population, accurate motion tracking is absolutely necessary for studying population activity with random-access based imaging methods. We demonstrate the potential of this imaging technique by measuring the correlation structure of large populations of nearby neurons in the mouse visual cortex, and find that the microcircuit correlation structure is stimulus-dependent. Three-dimensional random access multiphoton imaging with concurrent motion tracking provides a novel, powerful method to characterize the microcircuit activity in vivo.
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