ArticleFrontiers in cellular neuroscience2013
Sonic Hedgehog modulates EGFR dependent proliferation of neural stem cells during late mouse embryogenesis through EGFR transactivation.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Container-based framework for large-scale spiking network simulation.Frontiers in neuroscience · 2026Article
- EGF receptor in organ development, tissue homeostasis and regeneration.Journal of biomedical science · 2025Review
- Identification of Meibomian gland stem cell populations and mechanisms of aging.Nature communications · 2025Article
- Peripheral blood, lung and brain gene signatures in recovered and deceased patients with COVID-19.In silico pharmacology · 2025Article
- Calcium and Neural Stem Cell Proliferation.International journal of molecular sciences · 2024Review
- Glycoprotein non-metastatic melanoma B interacts with epidermal growth factor receptor to regulate neural stem cell survival and differentiation.Open medicine (Warsaw, Poland) · 2023Article
- Targeting hedgehog-driven mechanisms of drug-resistant cancers.Frontiers in molecular biosciences · 2023Review
- Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review.Open biology · 2022Review
- Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020Article
- Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury.CNS neuroscience & therapeutics · 2019Article
- Modulation of sonic hedgehog-induced mouse embryonic stem cell behaviours through E-cadherin expression and integrin β1-dependent F-actin formation.British journal of pharmacology · 2018Article
- Review
- Genetic deletion ofOncotarget · 2017Article
- PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone.Frontiers in cellular neuroscience · 2015Article
- Epidermal growth factor signaling in transformed cells.International review of cell and molecular biology · 2015Review
- Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium.IUBMB life · 2014Article
- Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy.Seminars in cell & developmental biology · 2014Review
- Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases astrogliogenesis.Frontiers in cellular neuroscience · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sonic Hedgehog (Shh/GLI) and EGFR signaling pathways modulate Neural Stem Cell (NSC) proliferation. How these signals cooperate is therefore critical for understanding normal brain development and function. Here we report a novel acute effect of Shh signaling on EGFR function. We show that during late neocortex development, Shh mediates the activation of the ERK1/2 signaling pathway in Radial Glial cells (RGC) through EGFR transactivation. This process is dependent on metalloprotease activity and accounts for almost 50% of the EGFR-dependent mitogenic response of late NSCs. Furthermore, in HeLa cancer cells, a well-known model for studying the EGFR receptor function, Shh also induces cell proliferation involving EGFR activation, as reflected by EGFR internalization and ERK1/2 phosphorylation. These findings may have important implications for understanding the mechanisms that regulate NSC proliferation during neurogenesis and may lead to novel approaches to the treatment of tumors.
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Registered trials
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