ReviewThe application of clinical genetics2013
Clinical impact of recent genetic discoveries in osteoporosis.
Review in The application of clinical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Association of a polygenic risk score with low trauma fractures in people with HIV - The swiss HIV cohort study.PloS one · 2026Article
- Clinical efficacy analysis of extrapedicular unilateral percutaneous vertebroplasty via the upper edge of the transverse process for lumbar osteoporotic vertebral compression fractures.BMC musculoskeletal disorders · 2025Article
- Low Bone Mineral Density in Hemophiliacs.Frontiers in medicine · 2022Review
- Article
- Genetic profiling of decreased bone mineral density in an independent sample of Caucasian women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Regular Muscle Electrical Stimulation Could Act Favorably On Bone Mineral Density in Healthy Aged Subjects.Frontiers in physiology · 2018Article
- Rapid phenotyping of knockout mice to identify genetic determinants of bone strength.The Journal of endocrinology · 2016Review
- Review
- Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.PLoS genetics · 2016Article
- A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Bone cements for percutaneous vertebroplasty and balloon kyphoplasty: Current status and future developments.Journal of orthopaedic translation · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Osteoporotic fracture carries an enormous public health burden in terms of mortality and morbidity. Current approaches to identify individuals at high risk for fracture are based on assessment of bone mineral density and presence of other osteoporosis risk factors. Bone mineral density and susceptibility to osteoporotic fractures are highly heritable, and over 60 loci have been robustly associated with one or both traits through genome-wide association studies carried out over the past 7 years. In this review, we discuss opportunities and challenges for incorporating these genetic discoveries into strategies to prevent osteoporotic fracture and translating new insights obtained from these discoveries into development of new therapeutic targets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.