ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Amplified cold transduction in native nociceptors by M-channel inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin.Physiological reports · 2022Article
- A population ofF1000Research · 2022Article
- The distinctive role of menthol in pain and analgesia: Mechanisms, practices, and advances.Frontiers in molecular neuroscience · 2022Review
- Odontoblast TRPC5 channels signal cold pain in teeth.Science advances · 2021Article
- Are TREK Channels Temperature Sensors?Frontiers in cellular neuroscience · 2021Review
- KCNQ/M-channels regulate mouse vagal bronchopulmonary C-fiber excitability and cough sensitivity.JCI insight · 2019Article
- Heat-resistant action potentials require TTX-resistant sodium channels NaThe Journal of general physiology · 2018Article
- M-type KBritish journal of pharmacology · 2018Review
- XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits.The Journal of pharmacology and experimental therapeutics · 2017Article
- Cellular and Molecular Targets of Menthol Actions.Frontiers in pharmacology · 2017Review
- Cold Temperature Encoding by Cutaneous TRPA1 and TRPM8-Carrying Fibers in the Mouse.Frontiers in molecular neuroscience · 2017Article
- New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.The Journal of biological chemistry · 2016Article
- Neuronal cell lines as model dorsal root ganglion neurons: A transcriptomic comparison.Molecular pain · 2016Article
- Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera.The European journal of neuroscience · 2015Article
- Cigarette smoke has sensory effects through nicotinic and TRPA1 but not TRPV1 receptors on the isolated mouse trachea and larynx.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- [Physiology of pain].Schmerz (Berlin, Germany) · 2015Review
- Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.Cell reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topically applied camphor elicits a sensation of cool, but nothing is known about how it affects cold temperature sensing. We found that camphor sensitizes a subpopulation of menthol-sensitive native cutaneous nociceptors in the mouse to cold, but desensitizes and partially blocks heterologously expressed TRPM8 (transient receptor potential cation channel subfamily M member 8). In contrast, camphor reduces potassium outward currents in cultured sensory neurons and, in cold nociceptors, the cold-sensitizing effects of camphor and menthol are additive. Using a membrane potential dye-based screening assay and heterologously expressed potassium channels, we found that the effects of camphor are mediated by inhibition of Kv7.2/3 channels subtypes that generate the M-current in neurons. In line with this finding, the specific M-current blocker XE991 reproduced the cold-sensitizing effect of camphor in nociceptors. However, the M-channel blocking effects of XE991 and camphor are not sufficient to initiate cold transduction but require a cold-activated inward current generated by TRPM8. The cold-sensitizing effects of XE991 and camphor are largest in high-threshold cold nociceptors. Low-threshold corneal cold thermoreceptors that express high levels of TRPM8 and lack potassium channels are not affected by camphor. We also found that menthol--like camphor--potently inhibits Kv7.2/3 channels. The apparent functional synergism arising from TRPM8 activation and M-current block can improve the effectiveness of topical coolants and cooling lotions, and may also enhance TRPM8-mediated analgesia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.