ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Long-lasting spinal oxytocin analgesia is ensured by the stimulation of allopregnanolone synthesis which potentiates GABA(A) receptor-mediated synaptic inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of Massage.bioRxiv : the preprint server for biology · 2026Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Sex and hormonal status influence the anxiolytic-like effect of oxytocin in mice.Neurobiology of stress · 2023Article
- Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain.Neuron · 2023Article
- Oxytocin Disturbs Vestibular Compensation and Modifies Behavioral Strategies in a Rodent Model of Acute Vestibulopathy.International journal of molecular sciences · 2022Article
- Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex.The journal of headache and pain · 2022Article
- The Comprehensive Neural Mechanism of Oxytocin in Analgesia.Current neuropharmacology · 2022Review
- Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases.International journal of molecular sciences · 2021Review
- Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway.Molecular medicine reports · 2020Article
- A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain.Scientific reports · 2020Article
- Recurrent antinociception induced by intrathecal or peripheral oxytocin in a neuropathic pain rat model.Experimental brain research · 2019Article
- Vasopressin and oxytocin in sensory neurones: expression, exocytotic release and regulation by lactation.Scientific reports · 2018Article
- Oxytocin, GABA, and TRPV1, the Analgesic Triad?Frontiers in molecular neuroscience · 2018Article
- Pituitary Hormones and Orofacial Pain.Frontiers in integrative neuroscience · 2018Article
- Oxytocin Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord.Frontiers in molecular neuroscience · 2018Article
- Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.Cell reports · 2017Article
- Oxytocin receptor DNA methylation in postpartum depression.Psychoneuroendocrinology · 2016Article
- Article
- Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II).Medical science monitor : international medical journal of experimental and clinical research · 2014Review
- Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone.Frontiers in cellular neuroscience · 2014Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothalamospinal control of spinal pain processing by oxytocin (OT) has received a lot of attention in recent years because of its potency to reduce pain symptoms in inflammatory and neuropathic conditions. However, cellular and molecular mechanisms underlying OT spinal antinociception are still poorly understood. In this study, we used biochemical, electrophysiological, and behavioral approaches to demonstrate that OT levels are elevated in the spinal cord of rats exhibiting pain symptoms, 24 h after the induction of inflammation with an intraplantar injection of λ-carrageenan. Using a selective OT receptor antagonist, we demonstrate that this elevated OT content is responsible for a tonic analgesia exerted on both mechanical and thermal modalities. This phenomenon appeared to be mediated by an OT receptor-mediated stimulation of neurosteroidogenesis, which leads to an increase in GABA(A) receptor-mediated synaptic inhibition in lamina II spinal cord neurons. We also provide evidence that this novel mechanism of OT-mediated spinal antinociception may be controlled by extracellular signal-related protein kinases, ERK1/2, after OT receptor activation. The oxytocinergic inhibitory control of spinal pain processing is emerging as an interesting target for future therapies since it recruits several molecular mechanisms, which are likely to exert a long-lasting analgesia through nongenomic and possibly genomic effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.