ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Synapsin function in GABA-ergic interneurons is required for short-term olfactory habituation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Shaping of olfactory responses by taste in a new assay for operant learning in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Semi-Automated Assessment of Long-Term Olfactory Habituation inBio-protocol · 2024Article
- Learning performance and GABAergic pathway link to deformed wing virus in the mushroom bodies of naturally infected honey bees.The Journal of experimental biology · 2024Article
- Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models.International journal of molecular sciences · 2024Review
- Forgetting as a form of adaptive engram cell plasticity.Nature reviews. Neuroscience · 2022Review
- GPCR voltage dependence controls neuronal plasticity and behavior.Nature communications · 2021Article
- Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021Review
- Habituation Learning Is a Widely Affected Mechanism in Drosophila Models of Intellectual Disability and Autism Spectrum Disorders.Biological psychiatry · 2019Article
- Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation ineLife · 2018Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
- Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy.Journal of biochemistry · 2017Article
- Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity.PLoS genetics · 2017Article
- Activity-Dependent Phosphorylation by CaMKIIδ Alters the CaFrontiers in synaptic neuroscience · 2017Article
- Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Synapsin is required to "boost" memory strength for highly salient events.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Synapsin determines memory strength after punishment- and relief-learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Molecular mechanisms of memory in imprinting.Neuroscience and biobehavioral reviews · 2015Review
- Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Modification of Male Courtship Motivation by Olfactory Habituation via the GABAA Receptor in Drosophila melanogaster.PloS one · 2015Article
- Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, short-term (STH) and long-term habituation (LTH) of olfactory avoidance behavior are believed to arise from the selective potentiation of GABAergic synapses between multiglomerular local circuit interneurons (LNs) and projection neurons in the antennal lobe. However, the underlying mechanisms remain poorly understood. Here, we show that synapsin (syn) function is necessary for STH and that syn(97)-null mutant defects in STH can be rescued by syn(+) cDNA expression solely in the LN1 subset of GABAergic local interneurons. As synapsin is a synaptic vesicle-clustering phosphoprotein, these observations identify a presynaptic mechanism for STH as well as the inhibitory interneurons in which this mechanism is deployed. Serine residues 6 and/or 533, potential kinase target sites of synapsin, are necessary for synapsin function suggesting that synapsin phosphorylation is essential for STH. Consistently, biochemical analyses using a phospho-synapsin-specific antiserum show that synapsin is a target of Ca(2+) calmodulin-dependent kinase II (CaMKII) phosphorylation in vivo. Additional behavioral and genetic observations demonstrate that CaMKII function is necessary in LNs for STH. Together, these data support a model in which CaMKII-mediated synapsin phosphorylation in LNs induces synaptic vesicle mobilization and thereby presynaptic facilitation of GABA release that underlies olfactory STH. Finally, the striking observation that LTH occurs normally in syn(97) mutants indicates that signaling pathways for STH and LTH diverge upstream of synapsin function in GABAergic interneurons.
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