ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Modeling fall propensity in Parkinson's disease: deficits in the attentional control of complex movements in rats with cortical-cholinergic and striatal-dopaminergic deafferentation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 78 citations in OpenAlex.
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- Falls Induced by Optogenetic Inhibition of Basal Forebrain Cholinergic Projections after Dorsomedial Striatal Dopamine Depletion in a Dual Disruption Model of Falling Vulnerability in Parkinson Disease.bioRxiv : the preprint server for biology · 2026Article
- Neurotransmitter Systems Underlying Freezing of Gait (FOG) in Parkinson's Disease.The European journal of neuroscience · 2026Review
- Aberrant Beta-Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- ActIIR inhibition improves motor outcome and preserves muscle fibers after experimental autoimmune neuritis.Acta neuropathologica communications · 2026Article
- Daily regulation of glucocerebrosidase activity and impact of fixed-time rotarod training in a mouse model ofFrontiers in cellular neuroscience · 2026Article
- Cholinergic System Changes in Dopa-Unresponsive Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Neurotoxic effects of rotenone and deltamethrin prolonged exposure on adult zebrafish.Scientific reports · 2025Article
- Recent advances of transcranial electrical stimulation in healthy aging and Parkinson's disease: Effects on dual tasking.Journal of Parkinson's disease · 2025Review
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- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
- Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease.Frontiers in aging neuroscience · 2024Review
- Balance beam crossing times are slower after noise exposure in rats.Frontiers in integrative neuroscience · 2023Article
- No Dopamine Agonist Modulation of Brain [Molecular pharmaceutics · 2022Article
- Cholinergic systems, attentional-motor integration, and cognitive control in Parkinson's disease.Progress in brain research · 2022Review
- Cholinesterase inhibitors for gait, balance, and fall in Parkinson disease: a meta-analysis.NPJ Parkinson's disease · 2021Article
- Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071.Psychopharmacology · 2021Article
- α4β2Annals of neurology · 2021Article
- Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive symptoms, complex movement deficits, and increased propensity for falls are interrelated and levodopa-unresponsive symptoms in patients with Parkinson's disease (PD). We developed a test system for the assessment of fall propensity in rats and tested the hypothesis that interactions between loss of cortical cholinergic and striatal dopaminergic afferents increase fall propensity. Rats were trained to traverse stationary and rotating rods, placed horizontally or at inclines, and while exposed to distractors. Rats also performed an operant Sustained Attention Task (SAT). Partial cortical cholinergic and/or caudate dopaminergic deafferentation were produced by bilateral infusions of 192 IgG-saporin (SAP) into the basal forebrain and/or 6-hydroxydopamine (6-OHDA) into the caudate nucleus, respectively, modeling the lesions seen in early PD. Rats with dual cholinergic-dopaminergic lesions (DL) fell more frequently than SAP or 6-OHDA rats. Falls in DL rats were associated with incomplete rebalancing after slips and low traversal speed. Ladder rung walking and pasta handling performance did not indicate sensorimotor deficits. SAT performance was impaired in DL and SAP rats; however, SAT performance and falls were correlated only in DL rats. Furthermore, in DL rats, but not in rats with only dopaminergic lesions, the placement and size of dopaminergic lesion correlated significantly with fall rates. The results support the hypothesis that after dual cholinergic-dopaminergic lesions, attentional resources can no longer be recruited to compensate for diminished striatal control of complex movement, thereby "unmasking" impaired striatal control of complex movements and yielding falls.
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