ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
miR-9 and miR-140-5p target FoxP2 and are regulated as a function of the social context of singing behavior in zebra finches.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
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- CHIRP-Seq: FOXP2 transcriptional targets in zebra finch brain include numerous speech and language-related genes.BMC neuroscience · 2025Article
- Neural stem cell secretome: a secret key to unlocking the power of regeneration in the adult and aging brain.Aging brain · 2025Article
- MeCP2 loss-of-function dysregulates microRNAs regionally and disrupts excitatory/inhibitory synaptic transmission balance.Hippocampus · 2022Article
- Inhibition of miR-128 Enhances Vocal Sequence Organization in Juvenile Songbirds.Frontiers in behavioral neuroscience · 2022Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- Music-listening regulates human microRNA expression.Epigenetics · 2021Article
- Social Isolation and Enrichment Induce Unique miRNA Signatures in the Prefrontal Cortex and Behavioral Changes in Mice.iScience · 2020Article
- Identification ofOpen biology · 2020Article
- Cerebrovascular miRNAs correlate with the clearance of Aβ through perivascular route in younger 3xTg-AD mice.Brain pathology (Zurich, Switzerland) · 2020Article
- Functional characterization of two enhancers located downstream FOXP2.BMC medical genetics · 2019Article
- The Role of miRNAs inGenetics · 2019Article
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- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells.PloS one · 2019Article
- Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1.Neuron · 2018Article
- Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure in swine.International journal of cardiology · 2018Article
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- Regulation of FSH expression by differentially expressed miR-186-5p in rat anterior adenohypophyseal cells.PloS one · 2018Article
- Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation.Journal of cellular and molecular medicine · 2018Article
- De novo PacBio long-read and phased avian genome assemblies correct and add to reference genes generated with intermediate and short reads.GigaScience · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Mutations in the FOXP2 gene cause speech and language impairments, accompanied by structural and functional abnormalities in brain regions underlying speech-related sensory-motor processing, including the striatum and cerebellum. The sequence and expression patterns of FOXP2 are highly conserved among higher vertebrates. In the zebra finch brain, FoxP2 is expressed in Area X, a striatal nucleus required for vocal learning, and reduced FoxP2 expression impairs dendritic development and vocal learning. The FoxP2 gene encodes a transcription factor that controls the expression of many downstream genes. However, how FOXP2 gene expression is regulated is not clearly understood. miRNAs regulate gene expression post-transcriptionally by targeting the 3'-untranslated regions (UTRs) of mRNAs, leading to translational suppression or mRNA degradation. In this study, we identified miR-9 and miR-140-5p as potential regulators of the FoxP2 gene. We show that both miR-9 and miR-140-5p target specific sequences in the FoxP2 3'-UTR and downregulate FoxP2 protein and mRNA expression in vitro. We also show that the expression of miR-9 and miR-140-5p in Area X of the zebra finch brain is regulated during song development in juvenile zebra finches. We further show that in adult zebra finches the expression of miR-9 and miR-140-5p in Area X is regulated as a function of the social context of song behavior in males singing undirected songs. Our findings reveal a post-transcriptional mechanism that regulates FoxP2 expression and suggest that social vocal behavior can influence the basal ganglia circuit controlling vocal learning via a miRNA-FoxP2 gene regulatory network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.