ArticleThe Journal of biological chemistry2013
The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Pathogenesis-related protein 10 in resistance to biotic stress: progress in elucidating functions, regulation and modes of action.Frontiers in plant science · 2023Pooled it
- Tuning reductase activity in monoterpene indole alkaloid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Biosynthesis and Functions of Flavonoids: Recent Advances From Studies Across Land Plant Diversity.Journal of the Royal Society of New Zealand · 2026Review
- Article
- Protection of naringenin chalcone by a pathogenesis-related 10 protein promotes flavonoid biosynthesis in Marchantia polymorpha.The New phytologist · 2025Article
- The evolution of flavonoid biosynthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Transcriptomic responses of Solanum tuberosum cv. Pirol to arbuscular mycorrhiza and potato virus Y (PVY) infection.Plant molecular biology · 2024Article
- Malnutrition and Allergies: Tipping the Immune Balance towards Health.Journal of clinical medicine · 2024Review
- Unlocking the Transcriptional Reprogramming Repertoire between Variety-Dependent Responses of Grapevine Berries to Infection byPlants (Basel, Switzerland) · 2024Article
- Deciphering the Interaction betweenLife (Basel, Switzerland) · 2024Article
- Phenolic profiling and bioactivity assessment ofHeliyon · 2024Article
- Insights into the Transcriptional Reprogramming of Peach Leaves Inoculated withPlants (Basel, Switzerland) · 2024Article
- Genome-wide identification of rubber tree pathogenesis-related 10 (PR-10) proteins with biological relevance to plant defense.Scientific reports · 2024Article
- Comparative transcriptome profiling and co-expression network analysis uncover the key genes associated with pear petal defense responses againstFrontiers in plant science · 2024Article
- Role of Small Molecule Ligands in IgE-Mediated Allergy.Current allergy and asthma reports · 2023Review
- The History and Science of the Major Birch Pollen Allergen Bet v 1.Biomolecules · 2023Review
- Anthocyanins: Metabolic Digestion, Bioavailability, Therapeutic Effects, Current Pharmaceutical/Industrial Use, and Innovation Potential.Antioxidants (Basel, Switzerland) · 2022Review
- Review
- Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation.Nature communications · 2022Article
- The Structural Flexibility of PR-10 Food Allergens.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenesis-related 10 (PR-10) proteins are involved in many aspects of plant biology but their molecular function is still unclear. They are related by sequence and structural homology to mammalian lipid transport and plant abscisic acid receptor proteins and are predicted to have cavities for ligand binding. Recently, three new members of the PR-10 family, the Fra a proteins, have been identified in strawberry, where they are required for the activity of the flavonoid biosynthesis pathway, which is essential for the development of color and flavor in fruits. Here, we show that Fra a proteins bind natural flavonoids with different selectivity and affinities in the low μm range. The structural analysis of Fra a 1 E and a Fra a 3-catechin complex indicates that loops L3, L5, and L7 surrounding the ligand-binding cavity show significant flexibility in the apo forms but close over the ligand in the Fra a 3-catechin complex. Our findings provide mechanistic insight on the function of Fra a proteins and suggest that PR-10 proteins, which are widespread in plants, may play a role in the control of secondary metabolic pathways by binding to metabolic intermediates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.